Establishment of an immortalized human endometrial stromal cell line with functional responses to ovarian stimuli

Munehiro Yuhki, Takashi Kajitani, Takakazu Mizuno, Yuko Aoki, Tetsuo Maruyama

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Studies on the mechanisms of decidualization and endometriosis are often hampered by lack of primary endometrial cells. To facilitate in vitro studies, we established a human endometrial stromal cell line, KC02-44D, immortalized with human telomerase reverse transcriptase. Upon exposure to ovarian stimuli, KC02-44D cells showed similar cytoskeletal marker or gene expression and biochemical phenotype to primary endometrial stromal cells. KC02-44D would be useful for studies of human endometrial function and its associated pathologies.

Original languageEnglish
Article number104
JournalReproductive Biology and Endocrinology
Volume9
DOIs
Publication statusPublished - 2011 Aug 1

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Stromal Cells
Cell Line
Endometriosis
Pathology
Phenotype
Gene Expression
human TERT protein
In Vitro Techniques

ASJC Scopus subject areas

  • Developmental Biology
  • Endocrinology
  • Reproductive Medicine
  • Medicine(all)

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Establishment of an immortalized human endometrial stromal cell line with functional responses to ovarian stimuli. / Yuhki, Munehiro; Kajitani, Takashi; Mizuno, Takakazu; Aoki, Yuko; Maruyama, Tetsuo.

In: Reproductive Biology and Endocrinology, Vol. 9, 104, 01.08.2011.

Research output: Contribution to journalArticle

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