Establishment of an immortalized human endometrial stromal cell line with functional responses to ovarian stimuli

Munehiro Yuhki, Takashi Kajitani, Takakazu Mizuno, Yuko Aoki, Tetsuo Maruyama

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16 Citations (Scopus)

Abstract

Studies on the mechanisms of decidualization and endometriosis are often hampered by lack of primary endometrial cells. To facilitate in vitro studies, we established a human endometrial stromal cell line, KC02-44D, immortalized with human telomerase reverse transcriptase. Upon exposure to ovarian stimuli, KC02-44D cells showed similar cytoskeletal marker or gene expression and biochemical phenotype to primary endometrial stromal cells. KC02-44D would be useful for studies of human endometrial function and its associated pathologies.

Original languageEnglish
Article number104
JournalReproductive Biology and Endocrinology
Volume9
DOIs
Publication statusPublished - 2011 Aug 1

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ASJC Scopus subject areas

  • Reproductive Medicine
  • Endocrinology
  • Obstetrics and Gynaecology
  • Developmental Biology

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