Establishment of an induced pluripotent stem cell line from a female domestic ferret (Mustela putorius furo) with an X chromosome instability

Sho Yoshimatsu, Rei Murakami, Mayutaka Nakajima, Tsukika Sato, Hiroshi Kawasaki, Hideyuki Okano

Research output: Contribution to journalArticlepeer-review

Abstract

The domestic ferret (ferret; Mustela putorius furo) is an important animal model for neuroscience and preclinical/veterinary medicine owing to its highly developed cerebral cortex and susceptibility to avian influenza and corona viruses. Nevertheless, there is a lack of in vitro ferret models, since immortal cell lines including induced pluripotent stem cells (iPSCs) of ferrets have been scarce. In this study, we established an iPSC line from ferret skin fibroblasts. The established iPSC line, fiPS-1, showed standard characteristics of pluripotency, but its X chromosome was unstable. Collectively, the present study provides a useful resource for in vitro model using the ferret.

Original languageEnglish
Article number102385
JournalStem Cell Research
Volume53
DOIs
Publication statusPublished - 2021 May

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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