Establishment of pten knockout medaka with transcription activator–like effector nucleases (TALENs) as a model of PTEN deficiency disease

Medicine & Life Sciences

• 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 11%
• Deficiency Diseases 95%
• Embryonic Structures 56%
• Eye 6%
• Fertilization 10%
• Genes 11%
• Genetic Suppression 13%
• Ketones 12%
• Lipids 6%
• Neoplasms 6%
• Oryzias 100%
• Phosphatidylinositol 3-Kinase 39%
• Phosphoprotein Phosphatases 11%
• Phosphoric Monoester Hydrolases 69%
• Preclinical Drug Evaluations 11%
• Sirolimus 10%
• Tail 9%
• Technology 6%
• Tensins 88%
• Up-Regulation 7%
• Zebrafish 9%

Agriculture & Biology

• Danio rerio 10%
• deficiency diseases 98%
• drugs 6%
• embryo (animal) 48%
• eyes 7%
• fertilization (reproduction) 8%
• genes 10%
• hatching 8%
• ketones 10%
• lipids 5%
• mice 5%
• mutants 22%
• mutation 6%
• neoplasms 14%
• nucleases 72%
• phosphatidylinositol 3-kinase 51%
• rapamycin 12%
• screening 6%
• tail 8%
• transcription (genetics) 50%

Chemical Compounds

• Drug 12%
• Effector 74%
• Lipid 15%
• LY294002 41%
• Mutation 19%
• N-Tosyl-L-Phenylalanyl Chloromethyl Ketone 53%
• Phosphatidylinositol 82%
• Phosphatidylinositol 3 Kinase Inhibitor 39%
• Protein 9%
• Time 8%