Estimation of the optical path length factor for functional imaging of an exposed cortex by principal component analysis

Kentaro Yokoyama, Motoshi Watanabe, Eiji Okada

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Activation of the cerebral cortex induces a localized change in the volume and oxygenation of the blood. Because the change in spectral reflectance of the cortex depends upon the concentration changes in oxy- and deoxy haemoglobin, multi-spectral imaging has been applied to investigate the functional activity of the exposed cortex related to oxy- and deoxy haemoglobin. However, brain tissue is a highly scattering medium, and the reflectance of cortical tissue depends on the mean optical path length of the detected light. The linear spectrographic analysis method without wavelength-dependent path length scaling may produce unreliable results in multi-spectral image analysis. In this study, we propose a method of estimating the wavelength-dependent path length factor from the principal component analysis of the multi-spectral images of the exposed cortex. The optical path-length factor estimated from the first principal component of the multi-spectral image of the cortical model and the absorption spectrum of haemoglobin agrees with that predicted by Monte Carlo simulation. The tendency of the optical path-length factor of the pig brain estimated from the first principal component of the multi-spectral images is almost the same as that of the cortical model.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsD.A. Boas
Pages168-179
Number of pages12
Volume5138
Publication statusPublished - 2003
EventPhoton Migration and Diffuse-Light Imaging - Munich, Germany
Duration: 2003 Jun 222003 Jun 23

Other

OtherPhoton Migration and Diffuse-Light Imaging
CountryGermany
CityMunich
Period03/6/2203/6/23

Fingerprint

cortexes
Hemoglobin
hemoglobin
principal components analysis
optical paths
Principal component analysis
Imaging techniques
brain
Brain
cerebral cortex
Tissue
Wavelength
spectral reflectance
Oxygenation
swine
oxygenation
image analysis
wavelengths
Image analysis
blood

Keywords

  • Exposed cortex
  • Monte Carlo simulation
  • Optical path-length factor
  • Principal component analysis

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Yokoyama, K., Watanabe, M., & Okada, E. (2003). Estimation of the optical path length factor for functional imaging of an exposed cortex by principal component analysis. In D. A. Boas (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 5138, pp. 168-179)

Estimation of the optical path length factor for functional imaging of an exposed cortex by principal component analysis. / Yokoyama, Kentaro; Watanabe, Motoshi; Okada, Eiji.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / D.A. Boas. Vol. 5138 2003. p. 168-179.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Yokoyama, K, Watanabe, M & Okada, E 2003, Estimation of the optical path length factor for functional imaging of an exposed cortex by principal component analysis. in DA Boas (ed.), Proceedings of SPIE - The International Society for Optical Engineering. vol. 5138, pp. 168-179, Photon Migration and Diffuse-Light Imaging, Munich, Germany, 03/6/22.
Yokoyama K, Watanabe M, Okada E. Estimation of the optical path length factor for functional imaging of an exposed cortex by principal component analysis. In Boas DA, editor, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 5138. 2003. p. 168-179
Yokoyama, Kentaro ; Watanabe, Motoshi ; Okada, Eiji. / Estimation of the optical path length factor for functional imaging of an exposed cortex by principal component analysis. Proceedings of SPIE - The International Society for Optical Engineering. editor / D.A. Boas. Vol. 5138 2003. pp. 168-179
@inproceedings{860bda783e3f4dffb64f859ec5ff25e6,
title = "Estimation of the optical path length factor for functional imaging of an exposed cortex by principal component analysis",
abstract = "Activation of the cerebral cortex induces a localized change in the volume and oxygenation of the blood. Because the change in spectral reflectance of the cortex depends upon the concentration changes in oxy- and deoxy haemoglobin, multi-spectral imaging has been applied to investigate the functional activity of the exposed cortex related to oxy- and deoxy haemoglobin. However, brain tissue is a highly scattering medium, and the reflectance of cortical tissue depends on the mean optical path length of the detected light. The linear spectrographic analysis method without wavelength-dependent path length scaling may produce unreliable results in multi-spectral image analysis. In this study, we propose a method of estimating the wavelength-dependent path length factor from the principal component analysis of the multi-spectral images of the exposed cortex. The optical path-length factor estimated from the first principal component of the multi-spectral image of the cortical model and the absorption spectrum of haemoglobin agrees with that predicted by Monte Carlo simulation. The tendency of the optical path-length factor of the pig brain estimated from the first principal component of the multi-spectral images is almost the same as that of the cortical model.",
keywords = "Exposed cortex, Monte Carlo simulation, Optical path-length factor, Principal component analysis",
author = "Kentaro Yokoyama and Motoshi Watanabe and Eiji Okada",
year = "2003",
language = "English",
volume = "5138",
pages = "168--179",
editor = "D.A. Boas",
booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",

}

TY - GEN

T1 - Estimation of the optical path length factor for functional imaging of an exposed cortex by principal component analysis

AU - Yokoyama, Kentaro

AU - Watanabe, Motoshi

AU - Okada, Eiji

PY - 2003

Y1 - 2003

N2 - Activation of the cerebral cortex induces a localized change in the volume and oxygenation of the blood. Because the change in spectral reflectance of the cortex depends upon the concentration changes in oxy- and deoxy haemoglobin, multi-spectral imaging has been applied to investigate the functional activity of the exposed cortex related to oxy- and deoxy haemoglobin. However, brain tissue is a highly scattering medium, and the reflectance of cortical tissue depends on the mean optical path length of the detected light. The linear spectrographic analysis method without wavelength-dependent path length scaling may produce unreliable results in multi-spectral image analysis. In this study, we propose a method of estimating the wavelength-dependent path length factor from the principal component analysis of the multi-spectral images of the exposed cortex. The optical path-length factor estimated from the first principal component of the multi-spectral image of the cortical model and the absorption spectrum of haemoglobin agrees with that predicted by Monte Carlo simulation. The tendency of the optical path-length factor of the pig brain estimated from the first principal component of the multi-spectral images is almost the same as that of the cortical model.

AB - Activation of the cerebral cortex induces a localized change in the volume and oxygenation of the blood. Because the change in spectral reflectance of the cortex depends upon the concentration changes in oxy- and deoxy haemoglobin, multi-spectral imaging has been applied to investigate the functional activity of the exposed cortex related to oxy- and deoxy haemoglobin. However, brain tissue is a highly scattering medium, and the reflectance of cortical tissue depends on the mean optical path length of the detected light. The linear spectrographic analysis method without wavelength-dependent path length scaling may produce unreliable results in multi-spectral image analysis. In this study, we propose a method of estimating the wavelength-dependent path length factor from the principal component analysis of the multi-spectral images of the exposed cortex. The optical path-length factor estimated from the first principal component of the multi-spectral image of the cortical model and the absorption spectrum of haemoglobin agrees with that predicted by Monte Carlo simulation. The tendency of the optical path-length factor of the pig brain estimated from the first principal component of the multi-spectral images is almost the same as that of the cortical model.

KW - Exposed cortex

KW - Monte Carlo simulation

KW - Optical path-length factor

KW - Principal component analysis

UR - http://www.scopus.com/inward/record.url?scp=1342331851&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1342331851&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:1342331851

VL - 5138

SP - 168

EP - 179

BT - Proceedings of SPIE - The International Society for Optical Engineering

A2 - Boas, D.A.

ER -