Eudesmane-type sesquiterpenoid and guaianolides from Kandelia candel in a screening program for compounds to overcome TRAIL resistance

Tomohiro Minakawa; Kazufumi Toume; Midori A. Arai; Samir K. Sadhu; Firoj Ahmed; Masami Ishibashi

doi:10.1021/np300179c

Eudesmane-type sesquiterpenoid and guaianolides from Kandelia candel in a screening program for compounds to overcome TRAIL resistance

Tomohiro Minakawa, Kazufumi Toume, Midori A. Arai, Samir K. Sadhu, Firoj Ahmed, Masami Ishibashi

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

In a screening program for natural products that can overcome TRAIL resistance, a new eudesmane-type sesquiterpenoid (1), three new guaianolides, mehirugins A-C (2-4), and two known guaianolides (5 and 6) were isolated from a MeOH extract of Kandelia candel leaves. Compounds 1 and 3-6 in combination with TRAIL showed cytotoxic activity in sensitizing TRAIL-resistant human gastric adenocarcinoma cells.

Original language	English
Pages (from-to)	1431-1435
Number of pages	5
Journal	Journal of Natural Products
Volume	75
Issue number	8
DOIs	https://doi.org/10.1021/np300179c
Publication status	Published - 2012 Aug 24
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np300179c

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Eudesmane-type sesquiterpenoid and guaianolides from Kandelia candel in a screening program for compounds to overcome TRAIL resistance. / Minakawa, Tomohiro; Toume, Kazufumi; Arai, Midori A.; Sadhu, Samir K.; Ahmed, Firoj; Ishibashi, Masami.

In: Journal of Natural Products, Vol. 75, No. 8, 24.08.2012, p. 1431-1435.

Research output: Contribution to journal › Article › peer-review

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