Abstract
Here we show that eugenol has an antidepressant-like activity comparable to that of imipramine using a forced swim test and a tail suspension test in mice. Furthermore, we show that both eugenol and imipramine induce brain-derived neurotrophic factor (BDNF) in the hippocampus with and without induction of metallothionein-III (MT-III), respectively. It may be possible that MT-III expression is involved in the exhibition of antidepressant-like activity of eugenol, not of imipramine.
| Original language | English |
|---|---|
| Pages (from-to) | 243-246 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 1011 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2004 Jun 18 |
Keywords
- Antidepressant
- BDNF
- Brain-derived neurotrophic factor
- Depression
- Disorders of the nervous system
- Eugenol
- Metallothionein-III
- Neuropsychiatric disorders
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology
Fingerprint Dive into the research topics of 'Eugenol exhibits antidepressant-like activity in mice and induces expression of metallothionein-III in the hippocampus'. Together they form a unique fingerprint.
Cite this
Irie, Y., Itokazu, N., Anjiki, N., Ishige, A., Watanabe, K., & Keung, W. M. (2004). Eugenol exhibits antidepressant-like activity in mice and induces expression of metallothionein-III in the hippocampus. Brain Research, 1011(2), 243-246. https://doi.org/10.1016/j.brainres.2004.03.040