Eugenol exhibits antidepressant-like activity in mice and induces expression of metallothionein-III in the hippocampus

Yoshifumi Irie; Nanae Itokazu; Naoko Anjiki; Atsushi Ishige; Kenji Watanabe; Wing Ming Keung

doi:10.1016/j.brainres.2004.03.040

Eugenol exhibits antidepressant-like activity in mice and induces expression of metallothionein-III in the hippocampus

Yoshifumi Irie, Nanae Itokazu, Naoko Anjiki, Atsushi Ishige, Kenji Watanabe, Wing Ming Keung

Faculty of Environment and Information Studies

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Here we show that eugenol has an antidepressant-like activity comparable to that of imipramine using a forced swim test and a tail suspension test in mice. Furthermore, we show that both eugenol and imipramine induce brain-derived neurotrophic factor (BDNF) in the hippocampus with and without induction of metallothionein-III (MT-III), respectively. It may be possible that MT-III expression is involved in the exhibition of antidepressant-like activity of eugenol, not of imipramine.

Original language	English
Pages (from-to)	243-246
Number of pages	4
Journal	Brain Research
Volume	1011
Issue number	2
DOIs	https://doi.org/10.1016/j.brainres.2004.03.040
Publication status	Published - 2004 Jun 18

Keywords

Antidepressant
BDNF
Brain-derived neurotrophic factor
Depression
Disorders of the nervous system
Eugenol
Metallothionein-III
Neuropsychiatric disorders

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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title = "Eugenol exhibits antidepressant-like activity in mice and induces expression of metallothionein-III in the hippocampus",

abstract = "Here we show that eugenol has an antidepressant-like activity comparable to that of imipramine using a forced swim test and a tail suspension test in mice. Furthermore, we show that both eugenol and imipramine induce brain-derived neurotrophic factor (BDNF) in the hippocampus with and without induction of metallothionein-III (MT-III), respectively. It may be possible that MT-III expression is involved in the exhibition of antidepressant-like activity of eugenol, not of imipramine.",

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AU - Irie, Yoshifumi

AU - Itokazu, Nanae

AU - Anjiki, Naoko

AU - Ishige, Atsushi

AU - Watanabe, Kenji

AU - Keung, Wing Ming

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