Abstract
Here we show that eugenol has an antidepressant-like activity comparable to that of imipramine using a forced swim test and a tail suspension test in mice. Furthermore, we show that both eugenol and imipramine induce brain-derived neurotrophic factor (BDNF) in the hippocampus with and without induction of metallothionein-III (MT-III), respectively. It may be possible that MT-III expression is involved in the exhibition of antidepressant-like activity of eugenol, not of imipramine.
Original language | English |
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Pages (from-to) | 243-246 |
Number of pages | 4 |
Journal | Brain Research |
Volume | 1011 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2004 Jun 18 |
Externally published | Yes |
Keywords
- Antidepressant
- BDNF
- Brain-derived neurotrophic factor
- Depression
- Disorders of the nervous system
- Eugenol
- Metallothionein-III
- Neuropsychiatric disorders
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology