Eugenol exhibits antidepressant-like activity in mice and induces expression of metallothionein-III in the hippocampus

Yoshifumi Irie, Nanae Itokazu, Naoko Anjiki, Atsushi Ishige, Kenji Watanabe, Wing Ming Keung

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Here we show that eugenol has an antidepressant-like activity comparable to that of imipramine using a forced swim test and a tail suspension test in mice. Furthermore, we show that both eugenol and imipramine induce brain-derived neurotrophic factor (BDNF) in the hippocampus with and without induction of metallothionein-III (MT-III), respectively. It may be possible that MT-III expression is involved in the exhibition of antidepressant-like activity of eugenol, not of imipramine.

Original languageEnglish
Pages (from-to)243-246
Number of pages4
JournalBrain Research
Volume1011
Issue number2
DOIs
Publication statusPublished - 2004 Jun 18

Keywords

  • Antidepressant
  • BDNF
  • Brain-derived neurotrophic factor
  • Depression
  • Disorders of the nervous system
  • Eugenol
  • Metallothionein-III
  • Neuropsychiatric disorders

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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