Eugenol exhibits antidepressant-like activity in mice and induces expression of metallothionein-III in the hippocampus

Yoshifumi Irie; Nanae Itokazu; Naoko Anjiki; Atsushi Ishige; Kenji Watanabe; Wing Ming Keung

doi:10.1016/j.brainres.2004.03.040

Eugenol exhibits antidepressant-like activity in mice and induces expression of metallothionein-III in the hippocampus

Yoshifumi Irie, Nanae Itokazu, Naoko Anjiki, Atsushi Ishige, Kenji Watanabe, Wing Ming Keung

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

Here we show that eugenol has an antidepressant-like activity comparable to that of imipramine using a forced swim test and a tail suspension test in mice. Furthermore, we show that both eugenol and imipramine induce brain-derived neurotrophic factor (BDNF) in the hippocampus with and without induction of metallothionein-III (MT-III), respectively. It may be possible that MT-III expression is involved in the exhibition of antidepressant-like activity of eugenol, not of imipramine.

Original language	English
Pages (from-to)	243-246
Number of pages	4
Journal	Brain Research
Volume	1011
Issue number	2
DOIs	https://doi.org/10.1016/j.brainres.2004.03.040
Publication status	Published - 2004 Jun 18
Externally published	Yes

Keywords

Antidepressant
BDNF
Brain-derived neurotrophic factor
Depression
Disorders of the nervous system
Eugenol
Metallothionein-III
Neuropsychiatric disorders

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/j.brainres.2004.03.040

Cite this

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title = "Eugenol exhibits antidepressant-like activity in mice and induces expression of metallothionein-III in the hippocampus",

abstract = "Here we show that eugenol has an antidepressant-like activity comparable to that of imipramine using a forced swim test and a tail suspension test in mice. Furthermore, we show that both eugenol and imipramine induce brain-derived neurotrophic factor (BDNF) in the hippocampus with and without induction of metallothionein-III (MT-III), respectively. It may be possible that MT-III expression is involved in the exhibition of antidepressant-like activity of eugenol, not of imipramine.",

keywords = "Antidepressant, BDNF, Brain-derived neurotrophic factor, Depression, Disorders of the nervous system, Eugenol, Metallothionein-III, Neuropsychiatric disorders",

author = "Yoshifumi Irie and Nanae Itokazu and Naoko Anjiki and Atsushi Ishige and Kenji Watanabe and Keung, {Wing Ming}",

note = "Funding Information: This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan.",

year = "2004",

month = jun,

day = "18",

doi = "10.1016/j.brainres.2004.03.040",

language = "English",

volume = "1011",

pages = "243--246",

journal = "Molecular Brain Research",

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TY - JOUR

T1 - Eugenol exhibits antidepressant-like activity in mice and induces expression of metallothionein-III in the hippocampus

AU - Irie, Yoshifumi

AU - Itokazu, Nanae

AU - Anjiki, Naoko

AU - Ishige, Atsushi

AU - Watanabe, Kenji

AU - Keung, Wing Ming

N1 - Funding Information: This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan.

PY - 2004/6/18

Y1 - 2004/6/18

N2 - Here we show that eugenol has an antidepressant-like activity comparable to that of imipramine using a forced swim test and a tail suspension test in mice. Furthermore, we show that both eugenol and imipramine induce brain-derived neurotrophic factor (BDNF) in the hippocampus with and without induction of metallothionein-III (MT-III), respectively. It may be possible that MT-III expression is involved in the exhibition of antidepressant-like activity of eugenol, not of imipramine.

AB - Here we show that eugenol has an antidepressant-like activity comparable to that of imipramine using a forced swim test and a tail suspension test in mice. Furthermore, we show that both eugenol and imipramine induce brain-derived neurotrophic factor (BDNF) in the hippocampus with and without induction of metallothionein-III (MT-III), respectively. It may be possible that MT-III expression is involved in the exhibition of antidepressant-like activity of eugenol, not of imipramine.

KW - Antidepressant

KW - BDNF

KW - Brain-derived neurotrophic factor

KW - Depression

KW - Disorders of the nervous system

KW - Eugenol

KW - Metallothionein-III

KW - Neuropsychiatric disorders

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DO - 10.1016/j.brainres.2004.03.040

M3 - Article

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AN - SCOPUS:2442488515

VL - 1011

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JO - Molecular Brain Research

JF - Molecular Brain Research

SN - 0006-8993

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ER -

Eugenol exhibits antidepressant-like activity in mice and induces expression of metallothionein-III in the hippocampus

Abstract

Keywords

ASJC Scopus subject areas

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