Eukaryotic flagella as motile tools for microfluidic devices

Hajime Nakamura, Kaori Kuribayashi, Hiroaki Onoe, Shoji Takeuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper describes a method of producing a rotating flagella array. Flagella of unicellular algae Chlamydomonas were released from the cell body, and selectively fixed on the glass substrate where methacryloyloxyethylphosphorylcholine (MPC)-polymer was patterned in order to prevent non-specific binding. They were then reactivated and rotated like micro motors when ATP was added. Using this experimental set-up, we monitored single flagellum continuously on site and changed its rotating speed by controlling the concentration of Ca2+. We believe that rotating flagella can be utilized as actuators for various microfluidic devices.

Original languageEnglish
Title of host publicationProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
EditorsJean-Louis Viovy, Patrick Tabeling, Stephanie Descroix, Laurent Malaquin
PublisherChemical and Biological Microsystems Society
Pages1222-1224
Number of pages3
ISBN (Electronic)9780979806407
Publication statusPublished - 2007
Event11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 - Paris, France
Duration: 2007 Oct 72007 Oct 11

Publication series

NameProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007

Conference

Conference11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
CountryFrance
CityParis
Period07/10/707/10/11

Keywords

  • Biomolecular motor
  • Flagella
  • Micro array
  • MPC-polymer

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Nakamura, H., Kuribayashi, K., Onoe, H., & Takeuchi, S. (2007). Eukaryotic flagella as motile tools for microfluidic devices. In J-L. Viovy, P. Tabeling, S. Descroix, & L. Malaquin (Eds.), Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 (pp. 1222-1224). (Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007). Chemical and Biological Microsystems Society.