Evaluating the severity of nonalcoholic steatohepatitis with superparamagnetic iron oxide-enhanced magnetic resonance imaging

Kengo Tomita, Akihiro Tanimoto, Rie Irie, Masahiro Kikuchi, Hirokazu Yokoyama, Toshiaki Teratani, Takahiro Suzuki, Takashi Taguchi, Masaaki Noguchi, Tamiko Ohkura, Toshifumi Hibi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Purpose: To evaluate the utility of noninvasive assessment of human nonalcoholic fatty liver disease (NAFLD) patients using superparamagnetic iron oxide (SPIO)-enhanced MRI. Materials and Methods: Nineteen NAFLD patients underwent SPIO-enhanced MRI. The values of τ, a time constant for an exponential approximation, were calculated using gradient-echo echo-planar imaging, and the values of %T2, a marker of the T2 relaxation effect of SPIO, were calculated using T2-weighted fast spin-echo images. Correlations between these values and the histological NAFLD activity scores were evaluated. The study protocol was approved by our Institutional Review Board and all patients gave informed consent. Results: There was a statistically significant relationship between the NAFLD activity scores and the τ values (r = 0.66, P = 0.002). The %T2 values were also significantly correlated with the NAFLD activity score (r = -0.58, P = 0.009). A cutoff τ value of 42.8 predicted "definitive NASH" (NAFLD activity score ≥5) with a specificity of 66.7% and a sensitivity of 99.9%, whereas a cutoff %T2 value of 32.5 predicted "definitive NASH" with a specificity of 72.7% and a sensitivity of 87.5%. Conclusion: Noninvasive SPIO-enhanced MRI may be helpful for identifying NASH patients among patients suspected of having NAFLD.

Original languageEnglish
Pages (from-to)1444-1450
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Volume28
Issue number6
DOIs
Publication statusPublished - 2008 Dec 1

Keywords

  • Magnetic resonance imaging
  • Nonalcoholic fatty liver disease
  • Nonalcoholic steatohepatitis
  • Superparamagnetic iron oxide

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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