Evaluation for antioxidant and renoprotective activity of olmesartan using nephrectomy rats

Daisuke Kadowaki, Makoto Anraku, Yuka Tasaki, Kazuaki Taguchi, Kazuki Shimoishi, Hakaru Seo, Sumio Hirata, Toru Maruyama, Masaki Otagiri

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Angiotensin II type 1 receptor blockers, which inhibit the rennin-angiotensin system, are used in the treatment of hypertension. In addition to their ability to lower blood pressure, these compounds have also been reported to protect organs, such as kidney and heart. Although the mechanisms of these protective effects are not fully understood, it is generally thought that their antioxidant effects likely play a role. The aim of the present study was to characterize the relationship between the antioxidant activity of olmesartan and its pharmacological actions such as renoprotective or blood pressure lowering effects, using 5/6 nephrectomy rats. In 5/6 nephrectomy rats, the potential antioxidant power, the ratio of oxidized to unoxidized albumin, as a marker of protein oxidation in blood, both systolic and diastolic blood pressure, plasma creatinine concentration, and amounts of protein excreted into the urine were significantly higher than the corresponding values for sham operated rats. However, olmesartan significantly suppressed these parameters within 8 weeks after oral administration in 5/6 nephrectomy rats. The oxidized albumin ratio was significantly decreased 4 weeks after the administration of olmesartan and these lower levels were maintained at 8 weeks. Furthermore, olmesartan improved radical scavenging activity of isolated albumin from rat plasma. Interestingly, a good correlation was found between the oxidized albumin ratios and renal function, whereas no correlation was found in the case of blood pressure. Based on those findings, we conclude that the antioxidant properties of olmesartan may be related to its renoprotective action rather than an antihypertensive effect.

Original languageEnglish
Pages (from-to)2041-2045
Number of pages5
JournalBiological and Pharmaceutical Bulletin
Volume32
Issue number12
DOIs
Publication statusPublished - 2009 Dec 1
Externally publishedYes

Keywords

  • Angiotensin II type 1 receptor blocker
  • Antioxidant
  • Hypertension
  • Olmesartan
  • Renoprotective effect

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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  • Cite this

    Kadowaki, D., Anraku, M., Tasaki, Y., Taguchi, K., Shimoishi, K., Seo, H., Hirata, S., Maruyama, T., & Otagiri, M. (2009). Evaluation for antioxidant and renoprotective activity of olmesartan using nephrectomy rats. Biological and Pharmaceutical Bulletin, 32(12), 2041-2045. https://doi.org/10.1248/bpb.32.2041