Evaluation of biofouling in stainless microfluidic channels for implantable multilayered dialysis device

Takashi Ota, Naoya To, Yoshihiko Kanno, Norihisa Miki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

An implantable artificial kidney can markedly improve the quality of life of renal disease patients. Our group has developed an implantable multilayered dialysis system consisting of microfluidic channels and dialysis membranes. Long-term evaluation is necessary for implant devices where biofouling is a critical factor, culminating in the deterioration of dialysis performance. Our previous work revealed that surface conditions, which depend on the manufacturing process, determine the amount of biofouling, and that electrolytic etching is the most suitable technique for forming a channel wall free of biofouling. In this study, we investigated the electrolytic etching conditions in detail. We conducted in vitro experiments for 7 d and evaluated the adhesion of biomaterials by scanning electron microscopy. The experiments revealed that a surface mirrorfinished by electrolytic etching effectively prevents biofouling.

Original languageEnglish
Article number06GN10
JournalJapanese Journal of Applied Physics
Volume56
Issue number6
DOIs
Publication statusPublished - 2017 Jun 1

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Biofouling
dialysis
Dialysis
Microfluidics
etching
Etching
evaluation
Dialysis membranes
kidneys
deterioration
adhesion
manufacturing
Biomaterials
membranes
Deterioration
scanning electron microscopy
Adhesion
Experiments
Scanning electron microscopy

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Evaluation of biofouling in stainless microfluidic channels for implantable multilayered dialysis device. / Ota, Takashi; To, Naoya; Kanno, Yoshihiko; Miki, Norihisa.

In: Japanese Journal of Applied Physics, Vol. 56, No. 6, 06GN10, 01.06.2017.

Research output: Contribution to journalArticle

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