Evaluation of hepatocyte-specific paramagnetic contrast media for MR imaging of hepatitis.

Akihiro Tanimoto, B. P. Kreft, Y. Baba, L. Zhao, J. P. Finn, C. C. Compton, D. D. Stark

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The hepatocyte-specific paramagnetic magnetic resonance (MR) contrast agents manganese-DPDP [N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'bis-(phosphate)] and gadobenate dimeglumine were used for diagnosing chemically induced hepatitis in rats. Ex vivo liver tissue relaxation times and in vivo MR image signal-to-noise ratios were compared before and after contrast agent administration. Ex vivo relaxometry and in vivo MR imaging showed that Mn-DPDP enhanced normal and diseased livers to the same degree at all time points from 5 to 120 minutes. Gadobenate dimeglumine showed reduced T1 and T2 enhancements in hepatitis relative to those of normal liver, in the early phase (5-30 minutes). However, these effects are offsetting, and as a result, MR imaging failed to allow distinction of diseased from normal livers. This surprising result observed in vivo was in fact predicted by applying the Bloch equation to our ex vivo data. Our results show that detection and quantitation of hepatitis with MR imaging enhanced with paramagnetic cell-specific contrast agents will be more difficult than anticipated.

Original languageEnglish
Pages (from-to)786-793
Number of pages8
JournalJournal of magnetic resonance imaging : JMRI
Volume3
Issue number5
Publication statusPublished - 1993 Sep
Externally publishedYes

Fingerprint

Contrast Media
Hepatitis
Hepatocytes
Magnetic Resonance Imaging
Liver Diseases
Magnetic Resonance Spectroscopy
Liver
Electron Spin Resonance Spectroscopy
Signal-To-Noise Ratio
Phosphates
N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid
gadobenic acid

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Tanimoto, A., Kreft, B. P., Baba, Y., Zhao, L., Finn, J. P., Compton, C. C., & Stark, D. D. (1993). Evaluation of hepatocyte-specific paramagnetic contrast media for MR imaging of hepatitis. Journal of magnetic resonance imaging : JMRI, 3(5), 786-793.

Evaluation of hepatocyte-specific paramagnetic contrast media for MR imaging of hepatitis. / Tanimoto, Akihiro; Kreft, B. P.; Baba, Y.; Zhao, L.; Finn, J. P.; Compton, C. C.; Stark, D. D.

In: Journal of magnetic resonance imaging : JMRI, Vol. 3, No. 5, 09.1993, p. 786-793.

Research output: Contribution to journalArticle

Tanimoto, A, Kreft, BP, Baba, Y, Zhao, L, Finn, JP, Compton, CC & Stark, DD 1993, 'Evaluation of hepatocyte-specific paramagnetic contrast media for MR imaging of hepatitis.', Journal of magnetic resonance imaging : JMRI, vol. 3, no. 5, pp. 786-793.
Tanimoto, Akihiro ; Kreft, B. P. ; Baba, Y. ; Zhao, L. ; Finn, J. P. ; Compton, C. C. ; Stark, D. D. / Evaluation of hepatocyte-specific paramagnetic contrast media for MR imaging of hepatitis. In: Journal of magnetic resonance imaging : JMRI. 1993 ; Vol. 3, No. 5. pp. 786-793.
@article{b0fcb17140a248cb9a7152b0f7d5983d,
title = "Evaluation of hepatocyte-specific paramagnetic contrast media for MR imaging of hepatitis.",
abstract = "The hepatocyte-specific paramagnetic magnetic resonance (MR) contrast agents manganese-DPDP [N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'bis-(phosphate)] and gadobenate dimeglumine were used for diagnosing chemically induced hepatitis in rats. Ex vivo liver tissue relaxation times and in vivo MR image signal-to-noise ratios were compared before and after contrast agent administration. Ex vivo relaxometry and in vivo MR imaging showed that Mn-DPDP enhanced normal and diseased livers to the same degree at all time points from 5 to 120 minutes. Gadobenate dimeglumine showed reduced T1 and T2 enhancements in hepatitis relative to those of normal liver, in the early phase (5-30 minutes). However, these effects are offsetting, and as a result, MR imaging failed to allow distinction of diseased from normal livers. This surprising result observed in vivo was in fact predicted by applying the Bloch equation to our ex vivo data. Our results show that detection and quantitation of hepatitis with MR imaging enhanced with paramagnetic cell-specific contrast agents will be more difficult than anticipated.",
author = "Akihiro Tanimoto and Kreft, {B. P.} and Y. Baba and L. Zhao and Finn, {J. P.} and Compton, {C. C.} and Stark, {D. D.}",
year = "1993",
month = "9",
language = "English",
volume = "3",
pages = "786--793",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - Evaluation of hepatocyte-specific paramagnetic contrast media for MR imaging of hepatitis.

AU - Tanimoto, Akihiro

AU - Kreft, B. P.

AU - Baba, Y.

AU - Zhao, L.

AU - Finn, J. P.

AU - Compton, C. C.

AU - Stark, D. D.

PY - 1993/9

Y1 - 1993/9

N2 - The hepatocyte-specific paramagnetic magnetic resonance (MR) contrast agents manganese-DPDP [N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'bis-(phosphate)] and gadobenate dimeglumine were used for diagnosing chemically induced hepatitis in rats. Ex vivo liver tissue relaxation times and in vivo MR image signal-to-noise ratios were compared before and after contrast agent administration. Ex vivo relaxometry and in vivo MR imaging showed that Mn-DPDP enhanced normal and diseased livers to the same degree at all time points from 5 to 120 minutes. Gadobenate dimeglumine showed reduced T1 and T2 enhancements in hepatitis relative to those of normal liver, in the early phase (5-30 minutes). However, these effects are offsetting, and as a result, MR imaging failed to allow distinction of diseased from normal livers. This surprising result observed in vivo was in fact predicted by applying the Bloch equation to our ex vivo data. Our results show that detection and quantitation of hepatitis with MR imaging enhanced with paramagnetic cell-specific contrast agents will be more difficult than anticipated.

AB - The hepatocyte-specific paramagnetic magnetic resonance (MR) contrast agents manganese-DPDP [N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'bis-(phosphate)] and gadobenate dimeglumine were used for diagnosing chemically induced hepatitis in rats. Ex vivo liver tissue relaxation times and in vivo MR image signal-to-noise ratios were compared before and after contrast agent administration. Ex vivo relaxometry and in vivo MR imaging showed that Mn-DPDP enhanced normal and diseased livers to the same degree at all time points from 5 to 120 minutes. Gadobenate dimeglumine showed reduced T1 and T2 enhancements in hepatitis relative to those of normal liver, in the early phase (5-30 minutes). However, these effects are offsetting, and as a result, MR imaging failed to allow distinction of diseased from normal livers. This surprising result observed in vivo was in fact predicted by applying the Bloch equation to our ex vivo data. Our results show that detection and quantitation of hepatitis with MR imaging enhanced with paramagnetic cell-specific contrast agents will be more difficult than anticipated.

UR - http://www.scopus.com/inward/record.url?scp=0027668769&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027668769&partnerID=8YFLogxK

M3 - Article

C2 - 8400566

AN - SCOPUS:0027668769

VL - 3

SP - 786

EP - 793

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 5

ER -