Abstract
Purpose: We implemented a fast gradient echo (GRE) sequence with an echo-planar imaging (EPI) read-out (FGRE-ET) to conduct myocardial perfusion studies on a conventional scanner. The accuracy of combined perfusion and viability studies is evaluated in comparison with coronary angiography (CAG). Materials and Methods: We enrolled 33 patients suspected of having coronary artery disease in this study. Short-axis perfusion images of the left ventricles were acquired following intravenous bolus injection of gadolinium-DTPA (0.05 mml/kg), both after myocardial loading by dipyridamole (0.56 mg/kg) and at rest. Viability studies were obtained using an inversion-recovery FGRE sequence. Radiologists performed blinded film readings. The findings with perfusion and the viability studies were compared with CAG on a segment-to-segment basis corresponding to the coronary arteries' territories. Stenosis equal to or greater than 75% in diameter was considered significant on CAG. The results were also compared with single photon emission computed tomography (SPECT) in 23 patients. Results: The combination of perfusion and viability studies showed 85.7% sensitivity, 88.9% specificity, and 87.2% accuracy in comparison with CAG. SPECT revealed respective rates of 71.7%, 78.3%, and 73.9% in 23 patients of this group. Conclusion: Myocardial perfusion studies using FGRE-ET were feasible and accurate, even on a conventional scanner.
| Original language | English |
|---|---|
| Pages (from-to) | 230-235 |
| Number of pages | 6 |
| Journal | Radiation Medicine - Medical Imaging and Radiation Oncology |
| Volume | 23 |
| Issue number | 4 |
| Publication status | Published - 2005 Jun |
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Keywords
- Ischemia
- Magnetic resonance
- Myocardium
- Perfusion
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiation
Cite this
Evaluation of ischemic heart disease on a 1.5 tesla scanner : Combined first-pass perfusion and viability study. / Okuda, Shigeo; Tanimoto, Akihiro; Satoh, Toru; Hashimoto, Jun; Shinmoto, Hiroshi; Higuchi, Nobuya; Nozaki, Atsushi; Kuribayashi, Sachio.
In: Radiation Medicine - Medical Imaging and Radiation Oncology, Vol. 23, No. 4, 06.2005, p. 230-235.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evaluation of ischemic heart disease on a 1.5 tesla scanner
T2 - Combined first-pass perfusion and viability study
AU - Okuda, Shigeo
AU - Tanimoto, Akihiro
AU - Satoh, Toru
AU - Hashimoto, Jun
AU - Shinmoto, Hiroshi
AU - Higuchi, Nobuya
AU - Nozaki, Atsushi
AU - Kuribayashi, Sachio
PY - 2005/6
Y1 - 2005/6
N2 - Purpose: We implemented a fast gradient echo (GRE) sequence with an echo-planar imaging (EPI) read-out (FGRE-ET) to conduct myocardial perfusion studies on a conventional scanner. The accuracy of combined perfusion and viability studies is evaluated in comparison with coronary angiography (CAG). Materials and Methods: We enrolled 33 patients suspected of having coronary artery disease in this study. Short-axis perfusion images of the left ventricles were acquired following intravenous bolus injection of gadolinium-DTPA (0.05 mml/kg), both after myocardial loading by dipyridamole (0.56 mg/kg) and at rest. Viability studies were obtained using an inversion-recovery FGRE sequence. Radiologists performed blinded film readings. The findings with perfusion and the viability studies were compared with CAG on a segment-to-segment basis corresponding to the coronary arteries' territories. Stenosis equal to or greater than 75% in diameter was considered significant on CAG. The results were also compared with single photon emission computed tomography (SPECT) in 23 patients. Results: The combination of perfusion and viability studies showed 85.7% sensitivity, 88.9% specificity, and 87.2% accuracy in comparison with CAG. SPECT revealed respective rates of 71.7%, 78.3%, and 73.9% in 23 patients of this group. Conclusion: Myocardial perfusion studies using FGRE-ET were feasible and accurate, even on a conventional scanner.
AB - Purpose: We implemented a fast gradient echo (GRE) sequence with an echo-planar imaging (EPI) read-out (FGRE-ET) to conduct myocardial perfusion studies on a conventional scanner. The accuracy of combined perfusion and viability studies is evaluated in comparison with coronary angiography (CAG). Materials and Methods: We enrolled 33 patients suspected of having coronary artery disease in this study. Short-axis perfusion images of the left ventricles were acquired following intravenous bolus injection of gadolinium-DTPA (0.05 mml/kg), both after myocardial loading by dipyridamole (0.56 mg/kg) and at rest. Viability studies were obtained using an inversion-recovery FGRE sequence. Radiologists performed blinded film readings. The findings with perfusion and the viability studies were compared with CAG on a segment-to-segment basis corresponding to the coronary arteries' territories. Stenosis equal to or greater than 75% in diameter was considered significant on CAG. The results were also compared with single photon emission computed tomography (SPECT) in 23 patients. Results: The combination of perfusion and viability studies showed 85.7% sensitivity, 88.9% specificity, and 87.2% accuracy in comparison with CAG. SPECT revealed respective rates of 71.7%, 78.3%, and 73.9% in 23 patients of this group. Conclusion: Myocardial perfusion studies using FGRE-ET were feasible and accurate, even on a conventional scanner.
KW - Ischemia
KW - Magnetic resonance
KW - Myocardium
KW - Perfusion
UR - http://www.scopus.com/inward/record.url?scp=22344432129&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=22344432129&partnerID=8YFLogxK
M3 - Article
C2 - 16012398
AN - SCOPUS:22344432129
VL - 23
SP - 230
EP - 235
JO - Japanese Journal of Radiology
JF - Japanese Journal of Radiology
SN - 1867-1071
IS - 4
ER -