Evaluation of NIRS data based on theoretical analysis of oxygen transport to cerebral tissue

Kazunori Oyama, Toshihiro Kondo, Hidefumi Komatsu, Toshihiko Sugiura

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

NIRS has been widely utilized for monitoring oxygen concentration of cerebral blood flow (CBF). However, meanings of signals measured by NIRS still have many unclear points. One of the factors is that the physiological mechanism of coupling between neuronal activity, metabolism and CBF is not clarified enough. In this study, we evaluate NIRS data based upon numerical simulation of oxygen transport to cerebral tissue. With a 2-dimensional mathematical model of oxygen transport from an arteriole to its surrounding tissue, we simulate the activity-dependent oxygenation changes. On the basis of calculated oxygen tension distribution, we derive quantities of two kinds of hemoglobin in the arteriole by using the oxygen dissociation curve, and theoretically decompose each hemoglobin change into its factors. This decomposition has revealed that NIRS data can reflect two types of physiological phenomena: a qualitative change caused by oxygen dissociation and a quantitative change caused by an increase of CBF. These results indicate that cellular oxygen consumption can be reflected more in the time courses of deoxygenated hemoglobin than those of oxygenated hemoglobin. It will be desirable to focus not only on oxygenated hemoglobin but also on deoxygenated hemoglobin when conducting evaluation of a brain function.

Original languageEnglish
Title of host publicationOxygen Transport to Tissue XXX
EditorsPer Liss, Peter Hansell, Duane Bruley, David Harrison
Pages181-186
Number of pages6
DOIs
Publication statusPublished - 2009 Dec 1

Publication series

NameAdvances in Experimental Medicine and Biology
Volume645
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Evaluation of NIRS data based on theoretical analysis of oxygen transport to cerebral tissue'. Together they form a unique fingerprint.

  • Cite this

    Oyama, K., Kondo, T., Komatsu, H., & Sugiura, T. (2009). Evaluation of NIRS data based on theoretical analysis of oxygen transport to cerebral tissue. In P. Liss, P. Hansell, D. Bruley, & D. Harrison (Eds.), Oxygen Transport to Tissue XXX (pp. 181-186). (Advances in Experimental Medicine and Biology; Vol. 645). https://doi.org/10.1007/978-0-387-85998-9_28