Evaluation of pancreatic fibrosis with acoustic radiation force impulse imaging and automated quantification of pancreatic tissue components

Yusuke Fujita, Minoru Kitago, Tokiya Abe, Osamu Itano, Masahiro Shinoda, Yuta Abe, Hiroshi Yagi, Taizo Hibi, Masatsugu Ishii, Yutaka Nakano, Kiyoshi Okuma, Masahiro Hashimoto, Ayano Takeuchi, Yohei Masugi, Masahiro Jinzaki, Michiie Sakamoto, Yuko Kitagawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives The aim of this study was to determine whether computer-assisted digital analysis and acoustic radiation force impulse (ARFI) imaging were useful for assessing pancreatic fibrosis, and if ARFI imaging predicted postoperative pancreatic fistula (POPF). Methods Seventy-eight patients scheduled to undergo pancreatic resection were enrolled. Shear wave velocity (SWV) at the pancreatic neck was measured preoperatively using ARFI imaging. Pancreatic tissue components on a whole slide image were quantified using an automatic image processing software. The relationship between SWV, fibrotic tissue content, and POPF incidence and clinical severity was analyzed. Results The median collagen fiber, fatty tissue, and acinar cell contents were 11.6%, 8.5%, and 61.3%, respectively. Unlike fatty tissue, collagen fiber content and acinar cells were correlated with SWV (ρ = 0.440, P < 0.001 and ρ =-0.428, P < 0.001, respectively). Although collagen fiber content and SWV were associated with the overall incidence of POPF (P = 0.004 and 0.001, respectively), collagen fiber content and SWV had no statistical correlation with clinically relevant POPF (P = 0.268 and 0.052, respectively). Conclusions We objectively quantified the pancreatic tissue components using an automatic image processing software. Shear wave velocity was significantly related to collagen fiber content and suggests that ARFI imaging can be useful for evaluating pancreatic fibrosis.

Original languageEnglish
Pages (from-to)1277-1282
Number of pages6
JournalPancreas
Volume47
Issue number10
DOIs
Publication statusPublished - 2018 Nov 1

Keywords

  • acoustic radiation force impulse
  • pancreatic fibrosis
  • postoperative pancreatic fistula
  • tissue fibrosis quantification

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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