Evaluation of pancreatic fibrosis with acoustic radiation force impulse imaging and automated quantification of pancreatic tissue components

Yusuke Fujita, Minoru Kitago, Tokiya Abe, Osamu Itano, Masahiro Shinoda, Yuta Abe, Hiroshi Yagi, Taizo Hibi, Masatsugu Ishii, Yutaka Nakano, Kiyoshi Okuma, Masahiro Hashimoto, Ayano Takeuchi, Yohei Masugi, Masahiro Jinzaki, Michiie Sakamoto, Yuukou Kitagawa

Research output: Contribution to journalArticle

Abstract

Objectives The aim of this study was to determine whether computer-assisted digital analysis and acoustic radiation force impulse (ARFI) imaging were useful for assessing pancreatic fibrosis, and if ARFI imaging predicted postoperative pancreatic fistula (POPF). Methods Seventy-eight patients scheduled to undergo pancreatic resection were enrolled. Shear wave velocity (SWV) at the pancreatic neck was measured preoperatively using ARFI imaging. Pancreatic tissue components on a whole slide image were quantified using an automatic image processing software. The relationship between SWV, fibrotic tissue content, and POPF incidence and clinical severity was analyzed. Results The median collagen fiber, fatty tissue, and acinar cell contents were 11.6%, 8.5%, and 61.3%, respectively. Unlike fatty tissue, collagen fiber content and acinar cells were correlated with SWV (ρ = 0.440, P < 0.001 and ρ =-0.428, P < 0.001, respectively). Although collagen fiber content and SWV were associated with the overall incidence of POPF (P = 0.004 and 0.001, respectively), collagen fiber content and SWV had no statistical correlation with clinically relevant POPF (P = 0.268 and 0.052, respectively). Conclusions We objectively quantified the pancreatic tissue components using an automatic image processing software. Shear wave velocity was significantly related to collagen fiber content and suggests that ARFI imaging can be useful for evaluating pancreatic fibrosis.

Original languageEnglish
Pages (from-to)1277-1282
Number of pages6
JournalPancreas
Volume47
Issue number10
DOIs
Publication statusPublished - 2018 Nov 1

Fingerprint

Elasticity Imaging Techniques
Pancreatic Fistula
Fibrosis
Collagen
Acinar Cells
Adipose Tissue
Software
Incidence

Keywords

  • acoustic radiation force impulse
  • pancreatic fibrosis
  • postoperative pancreatic fistula
  • tissue fibrosis quantification

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

Evaluation of pancreatic fibrosis with acoustic radiation force impulse imaging and automated quantification of pancreatic tissue components. / Fujita, Yusuke; Kitago, Minoru; Abe, Tokiya; Itano, Osamu; Shinoda, Masahiro; Abe, Yuta; Yagi, Hiroshi; Hibi, Taizo; Ishii, Masatsugu; Nakano, Yutaka; Okuma, Kiyoshi; Hashimoto, Masahiro; Takeuchi, Ayano; Masugi, Yohei; Jinzaki, Masahiro; Sakamoto, Michiie; Kitagawa, Yuukou.

In: Pancreas, Vol. 47, No. 10, 01.11.2018, p. 1277-1282.

Research output: Contribution to journalArticle

@article{9384b8341d1c4685946344ef970943e6,
title = "Evaluation of pancreatic fibrosis with acoustic radiation force impulse imaging and automated quantification of pancreatic tissue components",
abstract = "Objectives The aim of this study was to determine whether computer-assisted digital analysis and acoustic radiation force impulse (ARFI) imaging were useful for assessing pancreatic fibrosis, and if ARFI imaging predicted postoperative pancreatic fistula (POPF). Methods Seventy-eight patients scheduled to undergo pancreatic resection were enrolled. Shear wave velocity (SWV) at the pancreatic neck was measured preoperatively using ARFI imaging. Pancreatic tissue components on a whole slide image were quantified using an automatic image processing software. The relationship between SWV, fibrotic tissue content, and POPF incidence and clinical severity was analyzed. Results The median collagen fiber, fatty tissue, and acinar cell contents were 11.6{\%}, 8.5{\%}, and 61.3{\%}, respectively. Unlike fatty tissue, collagen fiber content and acinar cells were correlated with SWV (ρ = 0.440, P < 0.001 and ρ =-0.428, P < 0.001, respectively). Although collagen fiber content and SWV were associated with the overall incidence of POPF (P = 0.004 and 0.001, respectively), collagen fiber content and SWV had no statistical correlation with clinically relevant POPF (P = 0.268 and 0.052, respectively). Conclusions We objectively quantified the pancreatic tissue components using an automatic image processing software. Shear wave velocity was significantly related to collagen fiber content and suggests that ARFI imaging can be useful for evaluating pancreatic fibrosis.",
keywords = "acoustic radiation force impulse, pancreatic fibrosis, postoperative pancreatic fistula, tissue fibrosis quantification",
author = "Yusuke Fujita and Minoru Kitago and Tokiya Abe and Osamu Itano and Masahiro Shinoda and Yuta Abe and Hiroshi Yagi and Taizo Hibi and Masatsugu Ishii and Yutaka Nakano and Kiyoshi Okuma and Masahiro Hashimoto and Ayano Takeuchi and Yohei Masugi and Masahiro Jinzaki and Michiie Sakamoto and Yuukou Kitagawa",
year = "2018",
month = "11",
day = "1",
doi = "10.1097/MPA.0000000000001179",
language = "English",
volume = "47",
pages = "1277--1282",
journal = "Pancreas",
issn = "0885-3177",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

TY - JOUR

T1 - Evaluation of pancreatic fibrosis with acoustic radiation force impulse imaging and automated quantification of pancreatic tissue components

AU - Fujita, Yusuke

AU - Kitago, Minoru

AU - Abe, Tokiya

AU - Itano, Osamu

AU - Shinoda, Masahiro

AU - Abe, Yuta

AU - Yagi, Hiroshi

AU - Hibi, Taizo

AU - Ishii, Masatsugu

AU - Nakano, Yutaka

AU - Okuma, Kiyoshi

AU - Hashimoto, Masahiro

AU - Takeuchi, Ayano

AU - Masugi, Yohei

AU - Jinzaki, Masahiro

AU - Sakamoto, Michiie

AU - Kitagawa, Yuukou

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Objectives The aim of this study was to determine whether computer-assisted digital analysis and acoustic radiation force impulse (ARFI) imaging were useful for assessing pancreatic fibrosis, and if ARFI imaging predicted postoperative pancreatic fistula (POPF). Methods Seventy-eight patients scheduled to undergo pancreatic resection were enrolled. Shear wave velocity (SWV) at the pancreatic neck was measured preoperatively using ARFI imaging. Pancreatic tissue components on a whole slide image were quantified using an automatic image processing software. The relationship between SWV, fibrotic tissue content, and POPF incidence and clinical severity was analyzed. Results The median collagen fiber, fatty tissue, and acinar cell contents were 11.6%, 8.5%, and 61.3%, respectively. Unlike fatty tissue, collagen fiber content and acinar cells were correlated with SWV (ρ = 0.440, P < 0.001 and ρ =-0.428, P < 0.001, respectively). Although collagen fiber content and SWV were associated with the overall incidence of POPF (P = 0.004 and 0.001, respectively), collagen fiber content and SWV had no statistical correlation with clinically relevant POPF (P = 0.268 and 0.052, respectively). Conclusions We objectively quantified the pancreatic tissue components using an automatic image processing software. Shear wave velocity was significantly related to collagen fiber content and suggests that ARFI imaging can be useful for evaluating pancreatic fibrosis.

AB - Objectives The aim of this study was to determine whether computer-assisted digital analysis and acoustic radiation force impulse (ARFI) imaging were useful for assessing pancreatic fibrosis, and if ARFI imaging predicted postoperative pancreatic fistula (POPF). Methods Seventy-eight patients scheduled to undergo pancreatic resection were enrolled. Shear wave velocity (SWV) at the pancreatic neck was measured preoperatively using ARFI imaging. Pancreatic tissue components on a whole slide image were quantified using an automatic image processing software. The relationship between SWV, fibrotic tissue content, and POPF incidence and clinical severity was analyzed. Results The median collagen fiber, fatty tissue, and acinar cell contents were 11.6%, 8.5%, and 61.3%, respectively. Unlike fatty tissue, collagen fiber content and acinar cells were correlated with SWV (ρ = 0.440, P < 0.001 and ρ =-0.428, P < 0.001, respectively). Although collagen fiber content and SWV were associated with the overall incidence of POPF (P = 0.004 and 0.001, respectively), collagen fiber content and SWV had no statistical correlation with clinically relevant POPF (P = 0.268 and 0.052, respectively). Conclusions We objectively quantified the pancreatic tissue components using an automatic image processing software. Shear wave velocity was significantly related to collagen fiber content and suggests that ARFI imaging can be useful for evaluating pancreatic fibrosis.

KW - acoustic radiation force impulse

KW - pancreatic fibrosis

KW - postoperative pancreatic fistula

KW - tissue fibrosis quantification

UR - http://www.scopus.com/inward/record.url?scp=85055073128&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055073128&partnerID=8YFLogxK

U2 - 10.1097/MPA.0000000000001179

DO - 10.1097/MPA.0000000000001179

M3 - Article

C2 - 30286012

AN - SCOPUS:85055073128

VL - 47

SP - 1277

EP - 1282

JO - Pancreas

JF - Pancreas

SN - 0885-3177

IS - 10

ER -