TY - JOUR
T1 - Evaluation of short-term epigenetic age fluctuation
AU - Komaki, Shohei
AU - Ohmomo, Hideki
AU - Hachiya, Tsuyoshi
AU - Sutoh, Yoichi
AU - Ono, Kanako
AU - Furukawa, Ryohei
AU - Umekage, So
AU - Otsuka-Yamasaki, Yayoi
AU - Minabe, Shiori
AU - Takashima, Akira
AU - Tanno, Kozo
AU - Sasaki, Makoto
AU - Shimizu, Atsushi
N1 - Funding Information:
This study was supported by the Tohoku Medical Megabank Project (Special Account for the Reconstruction from the Great East Japan Earthquake) from the Japan Agency for Medical Research and Development.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Considerable effort has been spent on lowering and maintaining the epigenetic age. However, the extent to which epigenetic age fluctuates under normal conditions is poorly understood. Therefore, we analyzed methylation data from monocytes and peripheral blood mononuclear cells collected from two Japanese men. The ranges of the Pan-tissue, Skin and blood, and DNAm PhenoAge epigenetic age during 3 months were ≥ 5.62, ≥ 3.04, and ≥ 8.23 years, and the maximum daily changes were 5.21, 3.20, and 6.53 years, respectively. These fluctuations were not suppressed by correcting for cell-type composition. Although the underlying biological mechanism remains unclear, there was a nonnegligible degree of age fluctuation which should inform personalized clinical applications.
AB - Considerable effort has been spent on lowering and maintaining the epigenetic age. However, the extent to which epigenetic age fluctuates under normal conditions is poorly understood. Therefore, we analyzed methylation data from monocytes and peripheral blood mononuclear cells collected from two Japanese men. The ranges of the Pan-tissue, Skin and blood, and DNAm PhenoAge epigenetic age during 3 months were ≥ 5.62, ≥ 3.04, and ≥ 8.23 years, and the maximum daily changes were 5.21, 3.20, and 6.53 years, respectively. These fluctuations were not suppressed by correcting for cell-type composition. Although the underlying biological mechanism remains unclear, there was a nonnegligible degree of age fluctuation which should inform personalized clinical applications.
KW - Blood DNA methylation
KW - Epigenetic clock
KW - Healthy individuals
KW - Normal condition
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U2 - 10.1186/s13148-022-01293-9
DO - 10.1186/s13148-022-01293-9
M3 - Article
C2 - 35681206
AN - SCOPUS:85131702936
SN - 1868-7075
VL - 14
JO - Clinical Epigenetics
JF - Clinical Epigenetics
IS - 1
M1 - 76
ER -