Evaluation of short-term epigenetic age fluctuation

Shohei Komaki, Hideki Ohmomo, Tsuyoshi Hachiya, Yoichi Sutoh, Kanako Ono, Ryohei Furukawa, So Umekage, Yayoi Otsuka-Yamasaki, Shiori Minabe, Akira Takashima, Kozo Tanno, Makoto Sasaki, Atsushi Shimizu

Research output: Contribution to journalArticlepeer-review

Abstract

Considerable effort has been spent on lowering and maintaining the epigenetic age. However, the extent to which epigenetic age fluctuates under normal conditions is poorly understood. Therefore, we analyzed methylation data from monocytes and peripheral blood mononuclear cells collected from two Japanese men. The ranges of the Pan-tissue, Skin and blood, and DNAm PhenoAge epigenetic age during 3 months were ≥ 5.62, ≥ 3.04, and ≥ 8.23 years, and the maximum daily changes were 5.21, 3.20, and 6.53 years, respectively. These fluctuations were not suppressed by correcting for cell-type composition. Although the underlying biological mechanism remains unclear, there was a nonnegligible degree of age fluctuation which should inform personalized clinical applications.

Original languageEnglish
Article number76
JournalClinical Epigenetics
Volume14
Issue number1
DOIs
Publication statusPublished - 2022 Dec

Keywords

  • Blood DNA methylation
  • Epigenetic clock
  • Healthy individuals
  • Normal condition

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Developmental Biology
  • Genetics(clinical)

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