Evaluation of the alternative classification criteria of systemic lupus erythematosus established by Systemic Lupus International Collaborating Clinics (SLICC)

Kenji Oku, Tatsuya Atsumi, Yuji Akiyama, Hirofumi Amano, Naoto Azuma, Toshiyuki Bohgaki, Yu Funakubo Asanuma, Tetsuya Horita, Tadashi Hosoya, Kunihiro Ichinose, Masaru Kato, Yasuhiro Katsumata, Yasushi Kawaguchi, Atsushi Kawakami, Tomohiro Koga, Hitoshi Kohsaka, Yuya Kondo, Kanae Kubo, Masataka Kuwana, Akio MimoriTsuneyo Mimori, Toshihide Mimura, Kosaku Murakami, Kazuhisa Nakano, Shingo Nakayamada, Hiroshi Ogishima, Kazumasa Ohmura, Kazuyoshi Saito, Hajime Sano, Mihoko Shibuya, Yuko Takahashi, Yoshinari Takasaki, Tsutomu Takeuchi, Naoto Tamura, Yoshiya Tanaka, Hiroto Tsuboi, Shinichiro Tsunoda, Naoichiro Yukawa, Noriyuki Yamakawa, Kazuhiko Yamamoto, Takayuki Sumida

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: To evaluate the performance of the 2012 Systemic Lupus International Collaborating Clinics criteria (SLICC-12) on classifying systemic lupus erythematosus (SLE) in an uncontrolled multi-centered study with real-life scenario of the patients in Japan. Methods: This study comprised 495 patients with SLE or non-SLE rheumatic diseases and allied conditions from 12 institutes in Japan. Chart review of each patient was performed by the 27 expert rheumatologists and diagnosis of 487 cases reached to the consensus. Value of the SLICC-12 on SLE classification was analyzed comparing with the 1997 revised American College of Rheumatology SLE classification criteria (ACR-97) employing the expert-consented diagnoses. Results: Compared to the ACR-97, the SLICC-12 had a higher sensitivity (ACR-97 vs. SLICC-12: 0.88 vs. 0.99, p < .01) and comparable specificity (0.85 vs. 0.80). The rate of misclassification (0.14 vs. 0.11) or the area under the receiver operating characteristic curves (0.863 vs. 0.894) was not statistically different. In the cases that diagnoses corresponded in high rates among experts, both criteria showed high accordance of SLE classification over 85% with the expert diagnoses. Conclusion: Although employment of SLICC-12 for the classification for SLE should be carefully considered, the SLICC-12 showed the higher sensitivity on classifying SLE in Japanese population.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalModern Rheumatology
DOIs
Publication statusAccepted/In press - 2017 Nov 10

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Systemic Lupus Erythematosus
Japan
Rheumatic Diseases
ROC Curve
Population

Keywords

  • American College of Rheumatology (ACR)
  • classification criteria
  • Systemic lupus erythematosus (SLE)
  • systemic lupus erythematosus established by Systemic Lupus International Collaborating Clinics (SLICC)

ASJC Scopus subject areas

  • Rheumatology

Cite this

Evaluation of the alternative classification criteria of systemic lupus erythematosus established by Systemic Lupus International Collaborating Clinics (SLICC). / Oku, Kenji; Atsumi, Tatsuya; Akiyama, Yuji; Amano, Hirofumi; Azuma, Naoto; Bohgaki, Toshiyuki; Asanuma, Yu Funakubo; Horita, Tetsuya; Hosoya, Tadashi; Ichinose, Kunihiro; Kato, Masaru; Katsumata, Yasuhiro; Kawaguchi, Yasushi; Kawakami, Atsushi; Koga, Tomohiro; Kohsaka, Hitoshi; Kondo, Yuya; Kubo, Kanae; Kuwana, Masataka; Mimori, Akio; Mimori, Tsuneyo; Mimura, Toshihide; Murakami, Kosaku; Nakano, Kazuhisa; Nakayamada, Shingo; Ogishima, Hiroshi; Ohmura, Kazumasa; Saito, Kazuyoshi; Sano, Hajime; Shibuya, Mihoko; Takahashi, Yuko; Takasaki, Yoshinari; Takeuchi, Tsutomu; Tamura, Naoto; Tanaka, Yoshiya; Tsuboi, Hiroto; Tsunoda, Shinichiro; Yukawa, Naoichiro; Yamakawa, Noriyuki; Yamamoto, Kazuhiko; Sumida, Takayuki.

In: Modern Rheumatology, 10.11.2017, p. 1-7.

Research output: Contribution to journalArticle

Oku, K, Atsumi, T, Akiyama, Y, Amano, H, Azuma, N, Bohgaki, T, Asanuma, YF, Horita, T, Hosoya, T, Ichinose, K, Kato, M, Katsumata, Y, Kawaguchi, Y, Kawakami, A, Koga, T, Kohsaka, H, Kondo, Y, Kubo, K, Kuwana, M, Mimori, A, Mimori, T, Mimura, T, Murakami, K, Nakano, K, Nakayamada, S, Ogishima, H, Ohmura, K, Saito, K, Sano, H, Shibuya, M, Takahashi, Y, Takasaki, Y, Takeuchi, T, Tamura, N, Tanaka, Y, Tsuboi, H, Tsunoda, S, Yukawa, N, Yamakawa, N, Yamamoto, K & Sumida, T 2017, 'Evaluation of the alternative classification criteria of systemic lupus erythematosus established by Systemic Lupus International Collaborating Clinics (SLICC)', Modern Rheumatology, pp. 1-7. https://doi.org/10.1080/14397595.2017.1385154
Oku, Kenji ; Atsumi, Tatsuya ; Akiyama, Yuji ; Amano, Hirofumi ; Azuma, Naoto ; Bohgaki, Toshiyuki ; Asanuma, Yu Funakubo ; Horita, Tetsuya ; Hosoya, Tadashi ; Ichinose, Kunihiro ; Kato, Masaru ; Katsumata, Yasuhiro ; Kawaguchi, Yasushi ; Kawakami, Atsushi ; Koga, Tomohiro ; Kohsaka, Hitoshi ; Kondo, Yuya ; Kubo, Kanae ; Kuwana, Masataka ; Mimori, Akio ; Mimori, Tsuneyo ; Mimura, Toshihide ; Murakami, Kosaku ; Nakano, Kazuhisa ; Nakayamada, Shingo ; Ogishima, Hiroshi ; Ohmura, Kazumasa ; Saito, Kazuyoshi ; Sano, Hajime ; Shibuya, Mihoko ; Takahashi, Yuko ; Takasaki, Yoshinari ; Takeuchi, Tsutomu ; Tamura, Naoto ; Tanaka, Yoshiya ; Tsuboi, Hiroto ; Tsunoda, Shinichiro ; Yukawa, Naoichiro ; Yamakawa, Noriyuki ; Yamamoto, Kazuhiko ; Sumida, Takayuki. / Evaluation of the alternative classification criteria of systemic lupus erythematosus established by Systemic Lupus International Collaborating Clinics (SLICC). In: Modern Rheumatology. 2017 ; pp. 1-7.
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abstract = "Objective: To evaluate the performance of the 2012 Systemic Lupus International Collaborating Clinics criteria (SLICC-12) on classifying systemic lupus erythematosus (SLE) in an uncontrolled multi-centered study with real-life scenario of the patients in Japan. Methods: This study comprised 495 patients with SLE or non-SLE rheumatic diseases and allied conditions from 12 institutes in Japan. Chart review of each patient was performed by the 27 expert rheumatologists and diagnosis of 487 cases reached to the consensus. Value of the SLICC-12 on SLE classification was analyzed comparing with the 1997 revised American College of Rheumatology SLE classification criteria (ACR-97) employing the expert-consented diagnoses. Results: Compared to the ACR-97, the SLICC-12 had a higher sensitivity (ACR-97 vs. SLICC-12: 0.88 vs. 0.99, p < .01) and comparable specificity (0.85 vs. 0.80). The rate of misclassification (0.14 vs. 0.11) or the area under the receiver operating characteristic curves (0.863 vs. 0.894) was not statistically different. In the cases that diagnoses corresponded in high rates among experts, both criteria showed high accordance of SLE classification over 85{\%} with the expert diagnoses. Conclusion: Although employment of SLICC-12 for the classification for SLE should be carefully considered, the SLICC-12 showed the higher sensitivity on classifying SLE in Japanese population.",
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author = "Kenji Oku and Tatsuya Atsumi and Yuji Akiyama and Hirofumi Amano and Naoto Azuma and Toshiyuki Bohgaki and Asanuma, {Yu Funakubo} and Tetsuya Horita and Tadashi Hosoya and Kunihiro Ichinose and Masaru Kato and Yasuhiro Katsumata and Yasushi Kawaguchi and Atsushi Kawakami and Tomohiro Koga and Hitoshi Kohsaka and Yuya Kondo and Kanae Kubo and Masataka Kuwana and Akio Mimori and Tsuneyo Mimori and Toshihide Mimura and Kosaku Murakami and Kazuhisa Nakano and Shingo Nakayamada and Hiroshi Ogishima and Kazumasa Ohmura and Kazuyoshi Saito and Hajime Sano and Mihoko Shibuya and Yuko Takahashi and Yoshinari Takasaki and Tsutomu Takeuchi and Naoto Tamura and Yoshiya Tanaka and Hiroto Tsuboi and Shinichiro Tsunoda and Naoichiro Yukawa and Noriyuki Yamakawa and Kazuhiko Yamamoto and Takayuki Sumida",
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AU - Oku, Kenji

AU - Atsumi, Tatsuya

AU - Akiyama, Yuji

AU - Amano, Hirofumi

AU - Azuma, Naoto

AU - Bohgaki, Toshiyuki

AU - Asanuma, Yu Funakubo

AU - Horita, Tetsuya

AU - Hosoya, Tadashi

AU - Ichinose, Kunihiro

AU - Kato, Masaru

AU - Katsumata, Yasuhiro

AU - Kawaguchi, Yasushi

AU - Kawakami, Atsushi

AU - Koga, Tomohiro

AU - Kohsaka, Hitoshi

AU - Kondo, Yuya

AU - Kubo, Kanae

AU - Kuwana, Masataka

AU - Mimori, Akio

AU - Mimori, Tsuneyo

AU - Mimura, Toshihide

AU - Murakami, Kosaku

AU - Nakano, Kazuhisa

AU - Nakayamada, Shingo

AU - Ogishima, Hiroshi

AU - Ohmura, Kazumasa

AU - Saito, Kazuyoshi

AU - Sano, Hajime

AU - Shibuya, Mihoko

AU - Takahashi, Yuko

AU - Takasaki, Yoshinari

AU - Takeuchi, Tsutomu

AU - Tamura, Naoto

AU - Tanaka, Yoshiya

AU - Tsuboi, Hiroto

AU - Tsunoda, Shinichiro

AU - Yukawa, Naoichiro

AU - Yamakawa, Noriyuki

AU - Yamamoto, Kazuhiko

AU - Sumida, Takayuki

PY - 2017/11/10

Y1 - 2017/11/10

N2 - Objective: To evaluate the performance of the 2012 Systemic Lupus International Collaborating Clinics criteria (SLICC-12) on classifying systemic lupus erythematosus (SLE) in an uncontrolled multi-centered study with real-life scenario of the patients in Japan. Methods: This study comprised 495 patients with SLE or non-SLE rheumatic diseases and allied conditions from 12 institutes in Japan. Chart review of each patient was performed by the 27 expert rheumatologists and diagnosis of 487 cases reached to the consensus. Value of the SLICC-12 on SLE classification was analyzed comparing with the 1997 revised American College of Rheumatology SLE classification criteria (ACR-97) employing the expert-consented diagnoses. Results: Compared to the ACR-97, the SLICC-12 had a higher sensitivity (ACR-97 vs. SLICC-12: 0.88 vs. 0.99, p < .01) and comparable specificity (0.85 vs. 0.80). The rate of misclassification (0.14 vs. 0.11) or the area under the receiver operating characteristic curves (0.863 vs. 0.894) was not statistically different. In the cases that diagnoses corresponded in high rates among experts, both criteria showed high accordance of SLE classification over 85% with the expert diagnoses. Conclusion: Although employment of SLICC-12 for the classification for SLE should be carefully considered, the SLICC-12 showed the higher sensitivity on classifying SLE in Japanese population.

AB - Objective: To evaluate the performance of the 2012 Systemic Lupus International Collaborating Clinics criteria (SLICC-12) on classifying systemic lupus erythematosus (SLE) in an uncontrolled multi-centered study with real-life scenario of the patients in Japan. Methods: This study comprised 495 patients with SLE or non-SLE rheumatic diseases and allied conditions from 12 institutes in Japan. Chart review of each patient was performed by the 27 expert rheumatologists and diagnosis of 487 cases reached to the consensus. Value of the SLICC-12 on SLE classification was analyzed comparing with the 1997 revised American College of Rheumatology SLE classification criteria (ACR-97) employing the expert-consented diagnoses. Results: Compared to the ACR-97, the SLICC-12 had a higher sensitivity (ACR-97 vs. SLICC-12: 0.88 vs. 0.99, p < .01) and comparable specificity (0.85 vs. 0.80). The rate of misclassification (0.14 vs. 0.11) or the area under the receiver operating characteristic curves (0.863 vs. 0.894) was not statistically different. In the cases that diagnoses corresponded in high rates among experts, both criteria showed high accordance of SLE classification over 85% with the expert diagnoses. Conclusion: Although employment of SLICC-12 for the classification for SLE should be carefully considered, the SLICC-12 showed the higher sensitivity on classifying SLE in Japanese population.

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KW - classification criteria

KW - Systemic lupus erythematosus (SLE)

KW - systemic lupus erythematosus established by Systemic Lupus International Collaborating Clinics (SLICC)

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