Evaluation of the binding force between a biotinylated microbubble and a streptavidin-coated surface by ultrasound radiation

Toshihiko Sugiura; Klazina Kooiman; Marcia Emmer; Hendrik J. Vos; Annemieke Van Wamel; Nico De Jong

doi:10.1109/ULTSYM.2009.5441969

Evaluation of the binding force between a biotinylated microbubble and a streptavidin-coated surface by ultrasound radiation

Toshihiko Sugiura, Klazina Kooiman, Marcia Emmer, Hendrik J. Vos, Annemieke Van Wamel, Nico De Jong

Department of Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

For molecular imaging using ultrasound, targeted ultrasound contrast agents are used that consist of encapsulated gas microbubbles. For this application, the strength of adhesion between a microbubble and a cell surface is an important factor. This research focuses on the evaluation of the binding force between a streptavidin-coated surface, which mimics a cell surface, and biotinylated lipid coated microbubbles by detaching the microbubbles with ultrasound radiation force. Our results show that ultrasound radiation force can be used to determine the binding force between a targeted microbubble and a surface.

Original language	English
Title of host publication	2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1266-1269
Number of pages	4
ISBN (Print)	9781424443895
DOIs	https://doi.org/10.1109/ULTSYM.2009.5441969
Publication status	Published - 2009
Event	2009 IEEE International Ultrasonics Symposium, IUS 2009 - Rome, Italy Duration: 2009 Sept 20 → 2009 Sept 23

Publication series

Name	Proceedings - IEEE Ultrasonics Symposium
ISSN (Print)	1051-0117

Other

Other	2009 IEEE International Ultrasonics Symposium, IUS 2009
Country/Territory	Italy
City	Rome
Period	09/9/20 → 09/9/23

Keywords

Acoustic radiation force
Binding force
Biotin-streptavidin binding
Targeted microbubble

ASJC Scopus subject areas

Acoustics and Ultrasonics

Access to Document

10.1109/ULTSYM.2009.5441969

Cite this

Sugiura, T., Kooiman, K., Emmer, M., Vos, H. J., Van Wamel, A., & De Jong, N. (2009). Evaluation of the binding force between a biotinylated microbubble and a streptavidin-coated surface by ultrasound radiation. In 2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009 (pp. 1266-1269). [5441969] (Proceedings - IEEE Ultrasonics Symposium). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ULTSYM.2009.5441969

Evaluation of the binding force between a biotinylated microbubble and a streptavidin-coated surface by ultrasound radiation. / Sugiura, Toshihiko; Kooiman, Klazina; Emmer, Marcia et al.

2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009. Institute of Electrical and Electronics Engineers Inc., 2009. p. 1266-1269 5441969 (Proceedings - IEEE Ultrasonics Symposium).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Sugiura, T, Kooiman, K, Emmer, M, Vos, HJ, Van Wamel, A & De Jong, N 2009, Evaluation of the binding force between a biotinylated microbubble and a streptavidin-coated surface by ultrasound radiation. in 2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009., 5441969, Proceedings - IEEE Ultrasonics Symposium, Institute of Electrical and Electronics Engineers Inc., pp. 1266-1269, 2009 IEEE International Ultrasonics Symposium, IUS 2009, Rome, Italy, 09/9/20. https://doi.org/10.1109/ULTSYM.2009.5441969

Sugiura T, Kooiman K, Emmer M, Vos HJ, Van Wamel A, De Jong N. Evaluation of the binding force between a biotinylated microbubble and a streptavidin-coated surface by ultrasound radiation. In 2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009. Institute of Electrical and Electronics Engineers Inc. 2009. p. 1266-1269. 5441969. (Proceedings - IEEE Ultrasonics Symposium). doi: 10.1109/ULTSYM.2009.5441969

Sugiura, Toshihiko ; Kooiman, Klazina ; Emmer, Marcia et al. / Evaluation of the binding force between a biotinylated microbubble and a streptavidin-coated surface by ultrasound radiation. 2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009. Institute of Electrical and Electronics Engineers Inc., 2009. pp. 1266-1269 (Proceedings - IEEE Ultrasonics Symposium).

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title = "Evaluation of the binding force between a biotinylated microbubble and a streptavidin-coated surface by ultrasound radiation",

abstract = "For molecular imaging using ultrasound, targeted ultrasound contrast agents are used that consist of encapsulated gas microbubbles. For this application, the strength of adhesion between a microbubble and a cell surface is an important factor. This research focuses on the evaluation of the binding force between a streptavidin-coated surface, which mimics a cell surface, and biotinylated lipid coated microbubbles by detaching the microbubbles with ultrasound radiation force. Our results show that ultrasound radiation force can be used to determine the binding force between a targeted microbubble and a surface.",

keywords = "Acoustic radiation force, Binding force, Biotin-streptavidin binding, Targeted microbubble",

author = "Toshihiko Sugiura and Klazina Kooiman and Marcia Emmer and Vos, {Hendrik J.} and {Van Wamel}, Annemieke and {De Jong}, Nico",

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doi = "10.1109/ULTSYM.2009.5441969",

language = "English",

isbn = "9781424443895",

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AU - Sugiura, Toshihiko

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AU - Vos, Hendrik J.

AU - Van Wamel, Annemieke

AU - De Jong, Nico

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AB - For molecular imaging using ultrasound, targeted ultrasound contrast agents are used that consist of encapsulated gas microbubbles. For this application, the strength of adhesion between a microbubble and a cell surface is an important factor. This research focuses on the evaluation of the binding force between a streptavidin-coated surface, which mimics a cell surface, and biotinylated lipid coated microbubbles by detaching the microbubbles with ultrasound radiation force. Our results show that ultrasound radiation force can be used to determine the binding force between a targeted microbubble and a surface.

KW - Acoustic radiation force

KW - Binding force

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KW - Targeted microbubble

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Evaluation of the binding force between a biotinylated microbubble and a streptavidin-coated surface by ultrasound radiation

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Keywords

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