Evaluation of the binding force between a biotinylated microbubble and a streptavidin-coated surface by ultrasound radiation

Toshihiko Sugiura, Klazina Kooiman, Marcia Emmer, Hendrik J. Vos, Annemieke Van Wamel, Nico De Jong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

For molecular imaging using ultrasound, targeted ultrasound contrast agents are used that consist of encapsulated gas microbubbles. For this application, the strength of adhesion between a microbubble and a cell surface is an important factor. This research focuses on the evaluation of the binding force between a streptavidin-coated surface, which mimics a cell surface, and biotinylated lipid coated microbubbles by detaching the microbubbles with ultrasound radiation force. Our results show that ultrasound radiation force can be used to determine the binding force between a targeted microbubble and a surface.

Original languageEnglish
Title of host publication2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009
DOIs
Publication statusPublished - 2009 Dec 1
Event2009 IEEE International Ultrasonics Symposium, IUS 2009 - Rome, Italy
Duration: 2009 Sep 202009 Sep 23

Publication series

NameProceedings - IEEE Ultrasonics Symposium
ISSN (Print)1051-0117

Other

Other2009 IEEE International Ultrasonics Symposium, IUS 2009
CountryItaly
CityRome
Period09/9/2009/9/23

Keywords

  • Acoustic radiation force
  • Binding force
  • Biotin-streptavidin binding
  • Targeted microbubble

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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    Sugiura, T., Kooiman, K., Emmer, M., Vos, H. J., Van Wamel, A., & De Jong, N. (2009). Evaluation of the binding force between a biotinylated microbubble and a streptavidin-coated surface by ultrasound radiation. In 2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009 [5441969] (Proceedings - IEEE Ultrasonics Symposium). https://doi.org/10.1109/ULTSYM.2009.5441969