Evaluation of the new International Union Against Cancer TNM staging for gastric carcinoma

Hitoshi Katai, Kimio Yoshimura, Keiichi Maruyama, Mitsuru Sasako, Takeshi Sano

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

BACKGROUND. The lymph node (N) classification in the International Union Against Cancer (UICC) TNM staging system for gastric adenocarcinoma has been revised. The new classification is based on the number of positive regional lymph nodes instead of the anatomic location of the regional lymph node metastasis. Both classification systems were compared for prognostic significance. METHODS. A total of 4362 gastric carcinoma patients who underwent resection between 1969 and 1990 were analyzed. RESULTS. Thirteen percent of patients could not be staged according to the new system. Based on the previous classification, 647 patients were classified as pN1 and 711 patients as pN2. When reclassified, 587 patients remained pN1, 54 patients became pN2, and 6 patients became pN3. Of the 711 pN2 patients, 333 became pN1,267 remained pN2, and 111 patients became pN3. Both lymph node classification methods defined groups with widely differing prognoses. The prognoses of patients classified as new pN2 were more homogeneous than those of the group classified as old pN2. Survival of new pT4/pN1 patients was significantly better than that of other subgroups in Stage IV. Nine potential prognostic factors including lymph node metastasis, were studied in multivariate analysis. The hazard ratios were 1.38 (1.16-1.64) for pN1 and 2.55 (2.16-3.01) for pN2, based on the old classification. They were 1.51 (1.29-78) for pN1, 3.11 (2.56-3.78) for pN2, and 3.88 (2.98-5.05) for pN3, based on the new classification. CONCLUSIONS. The new N classification is superior as a prognostic factor to the old N classification, although there is inadequacy in stage grouping. (C) 2000 American Cancer Society.

Original languageEnglish
Pages (from-to)1796-1800
Number of pages5
JournalCancer
Volume88
Issue number8
DOIs
Publication statusPublished - 2000 Apr 15
Externally publishedYes

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Neoplasm Staging
Stomach
Carcinoma
Lymph Nodes
Neoplasm Metastasis
Adenocarcinoma
Multivariate Analysis

Keywords

  • Gastric carcinoma
  • Lymph node dissection
  • Lymphatic metastasis
  • Surgery

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Evaluation of the new International Union Against Cancer TNM staging for gastric carcinoma. / Katai, Hitoshi; Yoshimura, Kimio; Maruyama, Keiichi; Sasako, Mitsuru; Sano, Takeshi.

In: Cancer, Vol. 88, No. 8, 15.04.2000, p. 1796-1800.

Research output: Contribution to journalArticle

Katai, Hitoshi ; Yoshimura, Kimio ; Maruyama, Keiichi ; Sasako, Mitsuru ; Sano, Takeshi. / Evaluation of the new International Union Against Cancer TNM staging for gastric carcinoma. In: Cancer. 2000 ; Vol. 88, No. 8. pp. 1796-1800.
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AU - Maruyama, Keiichi

AU - Sasako, Mitsuru

AU - Sano, Takeshi

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N2 - BACKGROUND. The lymph node (N) classification in the International Union Against Cancer (UICC) TNM staging system for gastric adenocarcinoma has been revised. The new classification is based on the number of positive regional lymph nodes instead of the anatomic location of the regional lymph node metastasis. Both classification systems were compared for prognostic significance. METHODS. A total of 4362 gastric carcinoma patients who underwent resection between 1969 and 1990 were analyzed. RESULTS. Thirteen percent of patients could not be staged according to the new system. Based on the previous classification, 647 patients were classified as pN1 and 711 patients as pN2. When reclassified, 587 patients remained pN1, 54 patients became pN2, and 6 patients became pN3. Of the 711 pN2 patients, 333 became pN1,267 remained pN2, and 111 patients became pN3. Both lymph node classification methods defined groups with widely differing prognoses. The prognoses of patients classified as new pN2 were more homogeneous than those of the group classified as old pN2. Survival of new pT4/pN1 patients was significantly better than that of other subgroups in Stage IV. Nine potential prognostic factors including lymph node metastasis, were studied in multivariate analysis. The hazard ratios were 1.38 (1.16-1.64) for pN1 and 2.55 (2.16-3.01) for pN2, based on the old classification. They were 1.51 (1.29-78) for pN1, 3.11 (2.56-3.78) for pN2, and 3.88 (2.98-5.05) for pN3, based on the new classification. CONCLUSIONS. The new N classification is superior as a prognostic factor to the old N classification, although there is inadequacy in stage grouping. (C) 2000 American Cancer Society.

AB - BACKGROUND. The lymph node (N) classification in the International Union Against Cancer (UICC) TNM staging system for gastric adenocarcinoma has been revised. The new classification is based on the number of positive regional lymph nodes instead of the anatomic location of the regional lymph node metastasis. Both classification systems were compared for prognostic significance. METHODS. A total of 4362 gastric carcinoma patients who underwent resection between 1969 and 1990 were analyzed. RESULTS. Thirteen percent of patients could not be staged according to the new system. Based on the previous classification, 647 patients were classified as pN1 and 711 patients as pN2. When reclassified, 587 patients remained pN1, 54 patients became pN2, and 6 patients became pN3. Of the 711 pN2 patients, 333 became pN1,267 remained pN2, and 111 patients became pN3. Both lymph node classification methods defined groups with widely differing prognoses. The prognoses of patients classified as new pN2 were more homogeneous than those of the group classified as old pN2. Survival of new pT4/pN1 patients was significantly better than that of other subgroups in Stage IV. Nine potential prognostic factors including lymph node metastasis, were studied in multivariate analysis. The hazard ratios were 1.38 (1.16-1.64) for pN1 and 2.55 (2.16-3.01) for pN2, based on the old classification. They were 1.51 (1.29-78) for pN1, 3.11 (2.56-3.78) for pN2, and 3.88 (2.98-5.05) for pN3, based on the new classification. CONCLUSIONS. The new N classification is superior as a prognostic factor to the old N classification, although there is inadequacy in stage grouping. (C) 2000 American Cancer Society.

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KW - Lymph node dissection

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