Evaluation of therapeutic effects of astaxanthin on impairments in salivary secretion

Takashi Yamada, Koufuchi Ryo, Yoshinori Tai, Yoh Tamaki, Hiroko Inoue, Kenji Mishima, Kazuo Tsubota, Ichiro Saito

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The involvement of reactive oxygen species (ROS) in the pathophysiology of Sjögren's syndrome (SS), an autoimmune disorder, and irradiation-induced impairments in salivary secretion has been reported. Meanwhile, the strong antioxidant astaxanthin (Ast) has been suggested to have therapeutic effects on various diseases. In the present study, we examined the ROS scavenging capacity of Ast using a human salivary gland epithelial cell line (HSY) and investigated the effects of Ast on salivary secretion in a mouse model of irradiation-induced salivary gland dysfunction. Furthermore, we performed a clinical study of Ast in six SS patients and six normal individuals, quantifying the volume of saliva secretion and the level of oxidative stress markers in the saliva. Ast partially suppressed hydrogen peroxide-induced ROS in HSY cells. The mouse model demonstrated that the preadministration of Ast resulted in the suppression of irradiation-induced hyposalivation. Furthermore, the administration of Ast appeared to increase salivary output in both the SS and normal groups. The level of oxidative stress marker, hexanoyl-lysine, in the saliva was reduced after Ast intake. These results suggest that Ast might act as an ROS scavenger, providing benefits to SS patients with impaired salivary secretion.

Original languageEnglish
Pages (from-to)130-137
Number of pages8
JournalJournal of Clinical Biochemistry and Nutrition
Volume47
Issue number2
DOIs
Publication statusPublished - 2010 Sep

Fingerprint

Therapeutic Uses
Reactive Oxygen Species
Saliva
Oxidative stress
Irradiation
Salivary Glands
Oxidative Stress
astaxanthine
Xerostomia
Scavenging
Hydrogen Peroxide
Lysine
Antioxidants
Epithelial Cells
Cell Line

Keywords

  • Astaxanthin
  • Reactive oxygen species
  • Salivary secretion
  • Sjögren's syndrome

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Evaluation of therapeutic effects of astaxanthin on impairments in salivary secretion. / Yamada, Takashi; Ryo, Koufuchi; Tai, Yoshinori; Tamaki, Yoh; Inoue, Hiroko; Mishima, Kenji; Tsubota, Kazuo; Saito, Ichiro.

In: Journal of Clinical Biochemistry and Nutrition, Vol. 47, No. 2, 09.2010, p. 130-137.

Research output: Contribution to journalArticle

Yamada, Takashi ; Ryo, Koufuchi ; Tai, Yoshinori ; Tamaki, Yoh ; Inoue, Hiroko ; Mishima, Kenji ; Tsubota, Kazuo ; Saito, Ichiro. / Evaluation of therapeutic effects of astaxanthin on impairments in salivary secretion. In: Journal of Clinical Biochemistry and Nutrition. 2010 ; Vol. 47, No. 2. pp. 130-137.
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