Event-related desynchronization reflects downregulation of intracortical inhibition in human primary motor cortex

Mitsuaki Takemi, Yoshihisa Masakado, Meigen Liu, Junichi Ushiba

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

There is increasing interest in electroencephalogram (EEG)-based brain-computer interface (BCI) as a tool for rehabilitation of upper limb motor functions in hemiplegic stroke patients. This type of BCI often exploits mu and beta oscillations in EEG recorded over the sensorimotor areas, and their event-related desynchronization (ERD) following motor imagery is believed to represent increased sensorimotor cortex excitability. However, it remains unclear whether the sensorimotor cortex excitability is actually correlated with ERD. Thus we assessed the association of ERD with primary motor cortex (M1) excitability during motor imagery of right wrist movement. M1 excitability was tested by motor evoked potentials (MEPs), short-interval intracortical inhibition (SICI), and intracortical facilitation (ICF) with transcranial magnetic stimulation (TMS). Twenty healthy participants were recruited. The participants performed 7 s of rest followed by 5 s of motor imagery and received online visual feedback of the ERD magnitude of the contralateral hand M1 while performing the motor imagery task. TMS was applied to the right hand M1 when ERD exceeded predetermined thresholds during motor imagery. MEP amplitudes, SICI, and ICF were recorded from the agonist muscle of the imagined hand movement. Results showed that the large ERD during wrist motor imagery was associated with significantly increased MEP amplitudes and reduced SICI but no significant changes in ICF. Thus ERD magnitude during wrist motor imagery represents M1 excitability. This study provides electrophysiological evidence that a motor imagery task involving ERD may induce changes in corticospinal excitability similar to changes accompanying actual movements.

Original languageEnglish
Pages (from-to)1158-1166
Number of pages9
JournalJournal of Neurophysiology
Volume110
Issue number5
DOIs
Publication statusPublished - 2013 Sep 1

Fingerprint

Imagery (Psychotherapy)
Motor Cortex
Down-Regulation
Motor Evoked Potentials
Wrist
Brain-Computer Interfaces
Transcranial Magnetic Stimulation
Hand
Electroencephalography
Sensory Feedback
Inhibition (Psychology)
Upper Extremity
Healthy Volunteers
Rehabilitation
Stroke
Muscles

Keywords

  • Cortical excitability
  • Electroencephalogram
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Event-related desynchronization reflects downregulation of intracortical inhibition in human primary motor cortex. / Takemi, Mitsuaki; Masakado, Yoshihisa; Liu, Meigen; Ushiba, Junichi.

In: Journal of Neurophysiology, Vol. 110, No. 5, 01.09.2013, p. 1158-1166.

Research output: Contribution to journalArticle

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