Evidence for in vivo cerebrovascular neurogenic vasodilatation in the rat

Norihiro Suzuki, Fumio Gotoh, Jun Gotoh, Atsuo Koto

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

To determine the function of cerebrovascular parasympathetic nerves, the calibre of rat pial arteries was continuously measured when the nerves (the postganglionic fibres originating from the sphenopalatine ganglion) were electrically stimulated in vivo. The pial arteries (72.3 ± 2.8 μm) dilated immediately after electrical stimulation (5 V, 10 Hz, 0.5 ms, 1 min duration). Their diameter increased 4.7 ± 0.1% (p < 0.01), 6.3 ± 1.7%, 5.1 ± 0.3% (p < 0.05), 6.3 ± 1.4%, at 15, 30, 45 and 60 s after initiation of stimulation, respectively. No significant change was observed in systemic arterial blood pressure or the expiratory carbon dioxide content during stimulation. This is the first direct demonstration of in vivo cerebrovascular neurogenic vasodilatation in the rat.

Original languageEnglish
Pages (from-to)23-26
Number of pages4
JournalClinical Autonomic Research
Volume1
Issue number1
DOIs
Publication statusPublished - 1991 Mar 1

Keywords

  • Cerebral vessels
  • Electrical nerve stimulation
  • Parasympathetic nerve
  • Pterygopalatine ganglion
  • Sphenopalatine ganglion
  • Vasodilatation

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology

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