Evidence of immune tolerance to blood group antigens in a case of ABO-incompatible pediatric liver transplantation

H. Ohdan, W. Zhou, Y. Tanaka, T. Irei, Y. Fuchimoto, H. Egawa, T. Asahara

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In a 12-year-old patient with blood group O, who had received a partial liver graft 10 years ago from his father with blood group A, the levels of anti-A-specific antibodies (Abs) were persistently undetectable after the transplantation, while the levels of anti-B-specific Abs gradually increased and attained a plateau. Peripheral blood mononuclear cells (PBMCs) from this patient were engrafted into NOD/SCID mouse in order to investigate the immune response to donor-type blood group antigens. Even after sensitization with blood group-A erythrocytes, no anti-A Abs were detected in the serum samples of the mouse that received PBMCs from the blood group-O recipient of group-A liver allograft, however, immunoglobulins specific for antigens other than the A antigens were produced. Thus, we provide a possible evidence of immune tolerance to blood group antigens in this ABO-incompatible pediatric liver transplantation.

Original languageEnglish
Pages (from-to)2190-2194
Number of pages5
JournalAmerican Journal of Transplantation
Volume7
Issue number9
DOIs
Publication statusPublished - 2007 Sep

Keywords

  • ABO-incompatible transplantation
  • B-cell tolerance
  • Liver transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Evidence of immune tolerance to blood group antigens in a case of ABO-incompatible pediatric liver transplantation'. Together they form a unique fingerprint.

  • Cite this