Evolutionarily conserved mechanisms regulating neural development: lessons from the development of Drosophila peripheral nervous systems.

H. Okano, M. Okabe, A. Taguchi, K. Sawamoto

Research output: Contribution to journalReview article

3 Citations (Scopus)


Functions of genes regulating the development of Drosophila peripheral nervous systems are summarized herein. These genes can be classified into 6 groups: <1> prepattern genes, <2> proneural genes, <3> neurogenic genes, <4> neuronal precursor genes, <5> neuronal precursor type selector genes, and <6> cell-division and lineage genes. The mechanisms described herein provide excellent paradigms in the regulation of the development of other tissues in Drosophila, as well as in other organisms, including vertebrates. The roles of two different inhibitory mechanisms, i.e. Notch-signaling and Argos, in the development of Drosophila neural precursor cells are also discussed.

Original languageEnglish
Pages (from-to)139-150
Number of pages12
JournalHuman cell : official journal of Human Cell Research Society
Issue number3
Publication statusPublished - 1997 Sep


ASJC Scopus subject areas

  • Cell Biology
  • Cancer Research

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