Evolutionarily conserved mechanisms regulating neural development

lessons from the development of Drosophila peripheral nervous systems.

Hideyuki Okano, M. Okabe, A. Taguchi, K. Sawamoto

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Functions of genes regulating the development of Drosophila peripheral nervous systems are summarized herein. These genes can be classified into 6 groups: <1> prepattern genes, <2> proneural genes, <3> neurogenic genes, <4> neuronal precursor genes, <5> neuronal precursor type selector genes, and <6> cell-division and lineage genes. The mechanisms described herein provide excellent paradigms in the regulation of the development of other tissues in Drosophila, as well as in other organisms, including vertebrates. The roles of two different inhibitory mechanisms, i.e. Notch-signaling and Argos, in the development of Drosophila neural precursor cells are also discussed.

Original languageEnglish
Pages (from-to)139-150
Number of pages12
JournalHuman cell : official journal of Human Cell Research Society
Volume10
Issue number3
Publication statusPublished - 1997 Sep
Externally publishedYes

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Peripheral Nervous System
Drosophila
Genes
Cell Lineage
Cell Division
Vertebrates

ASJC Scopus subject areas

  • Cell Biology
  • Cancer Research

Cite this

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abstract = "Functions of genes regulating the development of Drosophila peripheral nervous systems are summarized herein. These genes can be classified into 6 groups: <1> prepattern genes, <2> proneural genes, <3> neurogenic genes, <4> neuronal precursor genes, <5> neuronal precursor type selector genes, and <6> cell-division and lineage genes. The mechanisms described herein provide excellent paradigms in the regulation of the development of other tissues in Drosophila, as well as in other organisms, including vertebrates. The roles of two different inhibitory mechanisms, i.e. Notch-signaling and Argos, in the development of Drosophila neural precursor cells are also discussed.",
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