Ex vivo and in vivo evaluation of the blood compatibility of surface- modified polyurethane catheters

Hiroyuki Inoue, Keiji Fujimoto, Yoshikimi Uyama, Yoshito Ikada

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

An assessment method relevant to the expected clinical application of biomaterials, when they are studied for improvement of blood-surface compatibility, is established. Segmented polyetherurethane (PU) was selected for the study as a polymer substrate for surface modification. The PU modification was carried out by surface graft polymerization of the water-soluble monomers acrylamide (AAm) and dimethyl acrylamide (DMAA). The in vivo blood compatibility of polyurethane was evaluated by implanting the catheter tube in the inferior vena cava of rabbits from the femoral vein after ligation of a distal site of the exposed femoral vein.

Original languageEnglish
Pages (from-to)255-264
Number of pages10
JournalJournal of Biomedical Materials Research
Volume35
Issue number2
DOIs
Publication statusPublished - 1997 May
Externally publishedYes

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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