TY - JOUR
T1 - Ex vivo and in vivo evaluation of the blood compatibility of surface- modified polyurethane catheters
AU - Inoue, Hiroyuki
AU - Fujimoto, Keiji
AU - Uyama, Yoshikimi
AU - Ikada, Yoshito
PY - 1997/5
Y1 - 1997/5
N2 - An assessment method relevant to the expected clinical application of biomaterials, when they are studied for improvement of blood-surface compatibility, is established. Segmented polyetherurethane (PU) was selected for the study as a polymer substrate for surface modification. The PU modification was carried out by surface graft polymerization of the water-soluble monomers acrylamide (AAm) and dimethyl acrylamide (DMAA). The in vivo blood compatibility of polyurethane was evaluated by implanting the catheter tube in the inferior vena cava of rabbits from the femoral vein after ligation of a distal site of the exposed femoral vein.
AB - An assessment method relevant to the expected clinical application of biomaterials, when they are studied for improvement of blood-surface compatibility, is established. Segmented polyetherurethane (PU) was selected for the study as a polymer substrate for surface modification. The PU modification was carried out by surface graft polymerization of the water-soluble monomers acrylamide (AAm) and dimethyl acrylamide (DMAA). The in vivo blood compatibility of polyurethane was evaluated by implanting the catheter tube in the inferior vena cava of rabbits from the femoral vein after ligation of a distal site of the exposed femoral vein.
UR - http://www.scopus.com/inward/record.url?scp=0031149296&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031149296&partnerID=8YFLogxK
U2 - 10.1002/(sici)1097-4636(199705)35:2<255::aid-jbm13>3.0.co;2-g
DO - 10.1002/(sici)1097-4636(199705)35:2<255::aid-jbm13>3.0.co;2-g
M3 - Article
C2 - 9135174
AN - SCOPUS:0031149296
SN - 1552-4973
VL - 35
SP - 255
EP - 264
JO - Journal of Biomedical Materials Research
JF - Journal of Biomedical Materials Research
IS - 2
ER -