Exaggerated secretion of atrial natriuretic polypeptide during dynamic exercise in patients with essential hypertension

Yoshihiko Saito, Kazuwa Nakao, Akira Sugawara, Kazunobu Nishimura, Narito Morii, Takayuki Yamada, Hiroshi Itoh, Shozo Shiono, Masashi Mukoyama, Hiroshi Arai, Makoto Sakamoto, Toshihiko Ban, Hiroo Imura

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The plasma concentration of atrial natriuretic polypeptide (ANP) was measured in nine patients with essential hypertension during two grades of exercise tests performed in the supine position on a bicycle ergometer. The plasma ANP concentration significantly increased from 97.0 ± 19.2 pg/ml to 107.6 ± 23.7 pg/ml (p < 0.05) during low-grade exercise (50% of the maximal heart rate) and from 96.2 ± 16.5 pg to 192.8 ± 30.7 pg/ml (p < 0.01) during high-grade exercise (75% of the maximal heart rate). During high-grade exercise plasma epinephrine and norepinephrine concentrations showed significant increases. The plasma ANP concentration was significantly correlated with systolic blood pressure (r = 0.51; p < 0.05). Patients with essential hypertension showed greater absolute increases in the plasma ANP concentration and systolic blood pressure during exercise compared to normotensive subjects. These results suggest that exercise stimulates secretion of ANP in response to its intensity in patients with essential hypertension and that a greater rise in atrial pressure, resulting from a greater elevation of systolic blood pressure, may be involved in the exaggerated secretion of ANP in patients with essential hypertension.

Original languageEnglish
Pages (from-to)1052-1057
Number of pages6
JournalAmerican Heart Journal
Volume116
Issue number4
DOIs
Publication statusPublished - 1988
Externally publishedYes

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Exercise
Blood Pressure
Peptides
Heart Rate
Atrial Pressure
Supine Position
Exercise Test
Epinephrine
Essential Hypertension
Norepinephrine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Exaggerated secretion of atrial natriuretic polypeptide during dynamic exercise in patients with essential hypertension. / Saito, Yoshihiko; Nakao, Kazuwa; Sugawara, Akira; Nishimura, Kazunobu; Morii, Narito; Yamada, Takayuki; Itoh, Hiroshi; Shiono, Shozo; Mukoyama, Masashi; Arai, Hiroshi; Sakamoto, Makoto; Ban, Toshihiko; Imura, Hiroo.

In: American Heart Journal, Vol. 116, No. 4, 1988, p. 1052-1057.

Research output: Contribution to journalArticle

Saito, Y, Nakao, K, Sugawara, A, Nishimura, K, Morii, N, Yamada, T, Itoh, H, Shiono, S, Mukoyama, M, Arai, H, Sakamoto, M, Ban, T & Imura, H 1988, 'Exaggerated secretion of atrial natriuretic polypeptide during dynamic exercise in patients with essential hypertension', American Heart Journal, vol. 116, no. 4, pp. 1052-1057. https://doi.org/10.1016/0002-8703(88)90159-7
Saito, Yoshihiko ; Nakao, Kazuwa ; Sugawara, Akira ; Nishimura, Kazunobu ; Morii, Narito ; Yamada, Takayuki ; Itoh, Hiroshi ; Shiono, Shozo ; Mukoyama, Masashi ; Arai, Hiroshi ; Sakamoto, Makoto ; Ban, Toshihiko ; Imura, Hiroo. / Exaggerated secretion of atrial natriuretic polypeptide during dynamic exercise in patients with essential hypertension. In: American Heart Journal. 1988 ; Vol. 116, No. 4. pp. 1052-1057.
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