Abstract
The plasma concentration of atrial natriuretic polypeptide (ANP) was measured in nine patients with essential hypertension during two grades of exercise tests performed in the supine position on a bicycle ergometer. The plasma ANP concentration significantly increased from 97.0 ± 19.2 pg/ml to 107.6 ± 23.7 pg/ml (p < 0.05) during low-grade exercise (50% of the maximal heart rate) and from 96.2 ± 16.5 pg to 192.8 ± 30.7 pg/ml (p < 0.01) during high-grade exercise (75% of the maximal heart rate). During high-grade exercise plasma epinephrine and norepinephrine concentrations showed significant increases. The plasma ANP concentration was significantly correlated with systolic blood pressure (r = 0.51; p < 0.05). Patients with essential hypertension showed greater absolute increases in the plasma ANP concentration and systolic blood pressure during exercise compared to normotensive subjects. These results suggest that exercise stimulates secretion of ANP in response to its intensity in patients with essential hypertension and that a greater rise in atrial pressure, resulting from a greater elevation of systolic blood pressure, may be involved in the exaggerated secretion of ANP in patients with essential hypertension.
| Original language | English |
|---|---|
| Pages (from-to) | 1052-1057 |
| Number of pages | 6 |
| Journal | American Heart Journal |
| Volume | 116 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1988 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Exaggerated secretion of atrial natriuretic polypeptide during dynamic exercise in patients with essential hypertension. / Saito, Yoshihiko; Nakao, Kazuwa; Sugawara, Akira; Nishimura, Kazunobu; Morii, Narito; Yamada, Takayuki; Itoh, Hiroshi; Shiono, Shozo; Mukoyama, Masashi; Arai, Hiroshi; Sakamoto, Makoto; Ban, Toshihiko; Imura, Hiroo.
In: American Heart Journal, Vol. 116, No. 4, 1988, p. 1052-1057.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Exaggerated secretion of atrial natriuretic polypeptide during dynamic exercise in patients with essential hypertension
AU - Saito, Yoshihiko
AU - Nakao, Kazuwa
AU - Sugawara, Akira
AU - Nishimura, Kazunobu
AU - Morii, Narito
AU - Yamada, Takayuki
AU - Itoh, Hiroshi
AU - Shiono, Shozo
AU - Mukoyama, Masashi
AU - Arai, Hiroshi
AU - Sakamoto, Makoto
AU - Ban, Toshihiko
AU - Imura, Hiroo
PY - 1988
Y1 - 1988
N2 - The plasma concentration of atrial natriuretic polypeptide (ANP) was measured in nine patients with essential hypertension during two grades of exercise tests performed in the supine position on a bicycle ergometer. The plasma ANP concentration significantly increased from 97.0 ± 19.2 pg/ml to 107.6 ± 23.7 pg/ml (p < 0.05) during low-grade exercise (50% of the maximal heart rate) and from 96.2 ± 16.5 pg to 192.8 ± 30.7 pg/ml (p < 0.01) during high-grade exercise (75% of the maximal heart rate). During high-grade exercise plasma epinephrine and norepinephrine concentrations showed significant increases. The plasma ANP concentration was significantly correlated with systolic blood pressure (r = 0.51; p < 0.05). Patients with essential hypertension showed greater absolute increases in the plasma ANP concentration and systolic blood pressure during exercise compared to normotensive subjects. These results suggest that exercise stimulates secretion of ANP in response to its intensity in patients with essential hypertension and that a greater rise in atrial pressure, resulting from a greater elevation of systolic blood pressure, may be involved in the exaggerated secretion of ANP in patients with essential hypertension.
AB - The plasma concentration of atrial natriuretic polypeptide (ANP) was measured in nine patients with essential hypertension during two grades of exercise tests performed in the supine position on a bicycle ergometer. The plasma ANP concentration significantly increased from 97.0 ± 19.2 pg/ml to 107.6 ± 23.7 pg/ml (p < 0.05) during low-grade exercise (50% of the maximal heart rate) and from 96.2 ± 16.5 pg to 192.8 ± 30.7 pg/ml (p < 0.01) during high-grade exercise (75% of the maximal heart rate). During high-grade exercise plasma epinephrine and norepinephrine concentrations showed significant increases. The plasma ANP concentration was significantly correlated with systolic blood pressure (r = 0.51; p < 0.05). Patients with essential hypertension showed greater absolute increases in the plasma ANP concentration and systolic blood pressure during exercise compared to normotensive subjects. These results suggest that exercise stimulates secretion of ANP in response to its intensity in patients with essential hypertension and that a greater rise in atrial pressure, resulting from a greater elevation of systolic blood pressure, may be involved in the exaggerated secretion of ANP in patients with essential hypertension.
UR - http://www.scopus.com/inward/record.url?scp=0023694715&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023694715&partnerID=8YFLogxK
U2 - 10.1016/0002-8703(88)90159-7
DO - 10.1016/0002-8703(88)90159-7
M3 - Article
C2 - 2972180
AN - SCOPUS:0023694715
VL - 116
SP - 1052
EP - 1057
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 4
ER -