Examination of the Disinfection Activity of Quick-drying Rubbing-type Antiseptics for Daily Use

Nagisa Ishiwata, Kanako Suzuki, Haruna Matsumoto, Keiko Yajima, Mariko Ono, Saori Tsuchida, Mari Hodotsuka, Mizuki Yuhara, Kayoko Maezawa, Tomoko Terajima, Noriko Kobayashi, Junko Kizu

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1 Citation (Scopus)

Abstract

Hand hygiene is important as a strategy to prevent hospital infection. In particular, alcohol-containing antiseptic hand rubs (alcohol-based hand rubs) are currently essential in clinical practice due to their simplicity and potent antiseptic effects. In this study, we compared the antiseptic and prolonged effects of representative rubbing-type antiseptics routinely employed in clinical practice, such as 0.2 w/v% benzalkonium chloride alcohol preparation, 0.5 w/v% quick-drying povidone-iodine alcohol preparation, and 0.2/0.5 w/v% quick-drying chlorhexidine gluconate alcohol preparations, applied in accordance with the glove juice method at various volumes. The subjects were female pharmacy students, who operated nozzle-type containers containing these rubbing-type antiseptics to collect typical samples by pushing the nozzle, as usually used by pharmacy students for hand/finger antisepsis, and the delivered volume was measured. The bacterial reduction rate after 1, 2, or 3 mL of each preparation was rubbed into the hands/fingers 3 times. All preparations exhibited favorable antiseptic effects when the sample was 2 mL or more. In addition, the antiseptic effects persisted for 4 hours when using 2 mL of preparation 3 times. Usually, the collected volumes per push of preparations containing 0.2 w/v% benzalkonium chloride and 0.5 w/v% chlorhexidine gluconate were approximately 2 mL. However, the volumes of preparations containing 0.5 w/v% povidone-iodine and 0.2 w/v% chlorhexidine gluconate were less than 2 mL. To achieve effective hand/finger antisepsis, the volumes of antiseptics applied must be considered.

Original languageEnglish
Pages (from-to)319-324
Number of pages6
JournalJapanese Journal of Environmental Infections
Volume24
Issue number5
DOIs
Publication statusPublished - 2009 Jan 1

Keywords

  • dose
  • glove juice method
  • hand/finger antisepsis
  • quick-drying rubbing-type antiseptics

ASJC Scopus subject areas

  • Epidemiology

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  • Cite this

    Ishiwata, N., Suzuki, K., Matsumoto, H., Yajima, K., Ono, M., Tsuchida, S., Hodotsuka, M., Yuhara, M., Maezawa, K., Terajima, T., Kobayashi, N., & Kizu, J. (2009). Examination of the Disinfection Activity of Quick-drying Rubbing-type Antiseptics for Daily Use. Japanese Journal of Environmental Infections, 24(5), 319-324. https://doi.org/10.4058/jsei.24.319