Execution mechanisms of programmed cell death by caspase (ICE/CED-3) family proteases

Masayuki Miura, Shin Hisahara, Takashi Araki, Hideyuki Okano

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Molecular genetic study of Caenorhabditis elegans revealed the cell death-executing gene ced-3. Structural and functional similarities between CED-3 and mammalian ICE family (caspase) gene products provide the evidence that mammalian caspases are common mediators in executing programmed cell death. These findings suggest that the execution mechanisms of cell death by caspase family protease may be evolutionarily conserved from worms to mammals. This report summarizes the unique properties of caspases in apoptosis.

Original languageEnglish
Pages (from-to)66-70
Number of pages5
JournalHeart and Vessels
Volume12
Issue numberSUPPL. 12
Publication statusPublished - 1997
Externally publishedYes

Fingerprint

Caspases
Peptide Hydrolases
Cell Death
Caenorhabditis elegans
Genes
Molecular Biology
Mammals
Apoptosis

Keywords

  • Apoptosis
  • Caspase
  • CED-3
  • ICE
  • Programmed cell death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Execution mechanisms of programmed cell death by caspase (ICE/CED-3) family proteases. / Miura, Masayuki; Hisahara, Shin; Araki, Takashi; Okano, Hideyuki.

In: Heart and Vessels, Vol. 12, No. SUPPL. 12, 1997, p. 66-70.

Research output: Contribution to journalArticle

Miura, M, Hisahara, S, Araki, T & Okano, H 1997, 'Execution mechanisms of programmed cell death by caspase (ICE/CED-3) family proteases', Heart and Vessels, vol. 12, no. SUPPL. 12, pp. 66-70.
Miura, Masayuki ; Hisahara, Shin ; Araki, Takashi ; Okano, Hideyuki. / Execution mechanisms of programmed cell death by caspase (ICE/CED-3) family proteases. In: Heart and Vessels. 1997 ; Vol. 12, No. SUPPL. 12. pp. 66-70.
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