Exercise Capacity and Association with Quality of Life in Peritoneal Dialysis Patients

Kiyotaka Uchiyama, Naoki Washida, Kaori Muraoka, Kohkichi Morimoto, Takahiro Kasai, Kentaro Yamaki, Kazutoshi Miyashita, Shu Wakino, Hiroshi Itoh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

BACKGROUND: Muscle wasting, common and progressive in uremic patients, is associated with a high probability for morbidity, lower health-related quality of life (HRQOL), and mortality. However, exercise tolerance in peritoneal dialysis (PD) patients has not been fully elucidated. The aim of this study was to evaluate exercise capacity, its determinants, and its association with HRQOL in PD patients. METHODS: Outpatients treated with PD at Keio University Hospital from December 2016 to March 2018 were included in this single-center cross-sectional observational study. Exercise capacity was assessed by incremental shuttle walking test (ISWT) and handgrip and quadriceps strength. In addition to evaluation of PD-related parameters, HRQOL was assessed by the Kidney Disease Quality of Life-Short Form questionnaire. RESULTS: Among the 50 recruited PD outpatients, age and PD vintage were 63.8 ± 9.6 and 3.8 ± 2.8 years, respectively. Physical examination revealed ISWT of 312.0 ± 138.2 m, handgrip strength of 27.5 ± 6.9 kg, and quadriceps strength of 23.3 ± 10.0 kg. Multivariate analysis showed that younger age and male sex were significantly associated with higher ISWT and handgrip and quadriceps strength. Skeletal mass index (SMI) remained a significant predictor of handgrip and quadriceps strength. Moreover, only ISWT was strongly correlated with higher HRQOL scores, including physical, mental, and kidney-specific domains, even after adjustment for age and sex. CONCLUSIONS: Exercise tolerance in PD patients was partially determined by age, sex, and SMI. Moreover, this is the first study to demonstrate the strong relationship between aerobic capacity and HRQOL in PD patients.

Original languageEnglish
Pages (from-to)66-73
Number of pages8
JournalPeritoneal dialysis international : journal of the International Society for Peritoneal Dialysis
Volume39
Issue number1
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Peritoneal Dialysis
Quality of Life
Exercise
Walking
Exercise Tolerance
Outpatients
Kidney Diseases
Physical Examination
Observational Studies
Multivariate Analysis
Cross-Sectional Studies
Morbidity
Kidney
Muscles
Mortality

Keywords

  • aerobic capacity
  • dual-energy x-ray absorptiometry
  • Incremental shuttle walking test
  • muscle strength
  • skeletal mass index

ASJC Scopus subject areas

  • Nephrology

Cite this

Exercise Capacity and Association with Quality of Life in Peritoneal Dialysis Patients. / Uchiyama, Kiyotaka; Washida, Naoki; Muraoka, Kaori; Morimoto, Kohkichi; Kasai, Takahiro; Yamaki, Kentaro; Miyashita, Kazutoshi; Wakino, Shu; Itoh, Hiroshi.

In: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, Vol. 39, No. 1, 01.01.2019, p. 66-73.

Research output: Contribution to journalArticle

Uchiyama, Kiyotaka ; Washida, Naoki ; Muraoka, Kaori ; Morimoto, Kohkichi ; Kasai, Takahiro ; Yamaki, Kentaro ; Miyashita, Kazutoshi ; Wakino, Shu ; Itoh, Hiroshi. / Exercise Capacity and Association with Quality of Life in Peritoneal Dialysis Patients. In: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. 2019 ; Vol. 39, No. 1. pp. 66-73.
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AU - Uchiyama, Kiyotaka

AU - Washida, Naoki

AU - Muraoka, Kaori

AU - Morimoto, Kohkichi

AU - Kasai, Takahiro

AU - Yamaki, Kentaro

AU - Miyashita, Kazutoshi

AU - Wakino, Shu

AU - Itoh, Hiroshi

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N2 - BACKGROUND: Muscle wasting, common and progressive in uremic patients, is associated with a high probability for morbidity, lower health-related quality of life (HRQOL), and mortality. However, exercise tolerance in peritoneal dialysis (PD) patients has not been fully elucidated. The aim of this study was to evaluate exercise capacity, its determinants, and its association with HRQOL in PD patients. METHODS: Outpatients treated with PD at Keio University Hospital from December 2016 to March 2018 were included in this single-center cross-sectional observational study. Exercise capacity was assessed by incremental shuttle walking test (ISWT) and handgrip and quadriceps strength. In addition to evaluation of PD-related parameters, HRQOL was assessed by the Kidney Disease Quality of Life-Short Form questionnaire. RESULTS: Among the 50 recruited PD outpatients, age and PD vintage were 63.8 ± 9.6 and 3.8 ± 2.8 years, respectively. Physical examination revealed ISWT of 312.0 ± 138.2 m, handgrip strength of 27.5 ± 6.9 kg, and quadriceps strength of 23.3 ± 10.0 kg. Multivariate analysis showed that younger age and male sex were significantly associated with higher ISWT and handgrip and quadriceps strength. Skeletal mass index (SMI) remained a significant predictor of handgrip and quadriceps strength. Moreover, only ISWT was strongly correlated with higher HRQOL scores, including physical, mental, and kidney-specific domains, even after adjustment for age and sex. CONCLUSIONS: Exercise tolerance in PD patients was partially determined by age, sex, and SMI. Moreover, this is the first study to demonstrate the strong relationship between aerobic capacity and HRQOL in PD patients.

AB - BACKGROUND: Muscle wasting, common and progressive in uremic patients, is associated with a high probability for morbidity, lower health-related quality of life (HRQOL), and mortality. However, exercise tolerance in peritoneal dialysis (PD) patients has not been fully elucidated. The aim of this study was to evaluate exercise capacity, its determinants, and its association with HRQOL in PD patients. METHODS: Outpatients treated with PD at Keio University Hospital from December 2016 to March 2018 were included in this single-center cross-sectional observational study. Exercise capacity was assessed by incremental shuttle walking test (ISWT) and handgrip and quadriceps strength. In addition to evaluation of PD-related parameters, HRQOL was assessed by the Kidney Disease Quality of Life-Short Form questionnaire. RESULTS: Among the 50 recruited PD outpatients, age and PD vintage were 63.8 ± 9.6 and 3.8 ± 2.8 years, respectively. Physical examination revealed ISWT of 312.0 ± 138.2 m, handgrip strength of 27.5 ± 6.9 kg, and quadriceps strength of 23.3 ± 10.0 kg. Multivariate analysis showed that younger age and male sex were significantly associated with higher ISWT and handgrip and quadriceps strength. Skeletal mass index (SMI) remained a significant predictor of handgrip and quadriceps strength. Moreover, only ISWT was strongly correlated with higher HRQOL scores, including physical, mental, and kidney-specific domains, even after adjustment for age and sex. CONCLUSIONS: Exercise tolerance in PD patients was partially determined by age, sex, and SMI. Moreover, this is the first study to demonstrate the strong relationship between aerobic capacity and HRQOL in PD patients.

KW - aerobic capacity

KW - dual-energy x-ray absorptiometry

KW - Incremental shuttle walking test

KW - muscle strength

KW - skeletal mass index

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