Abstract
BACKGROUND: Muscle wasting, common and progressive in uremic patients, is associated with a high probability for morbidity, lower health-related quality of life (HRQOL), and mortality. However, exercise tolerance in peritoneal dialysis (PD) patients has not been fully elucidated. The aim of this study was to evaluate exercise capacity, its determinants, and its association with HRQOL in PD patients. METHODS: Outpatients treated with PD at Keio University Hospital from December 2016 to March 2018 were included in this single-center cross-sectional observational study. Exercise capacity was assessed by incremental shuttle walking test (ISWT) and handgrip and quadriceps strength. In addition to evaluation of PD-related parameters, HRQOL was assessed by the Kidney Disease Quality of Life-Short Form questionnaire. RESULTS: Among the 50 recruited PD outpatients, age and PD vintage were 63.8 ± 9.6 and 3.8 ± 2.8 years, respectively. Physical examination revealed ISWT of 312.0 ± 138.2 m, handgrip strength of 27.5 ± 6.9 kg, and quadriceps strength of 23.3 ± 10.0 kg. Multivariate analysis showed that younger age and male sex were significantly associated with higher ISWT and handgrip and quadriceps strength. Skeletal mass index (SMI) remained a significant predictor of handgrip and quadriceps strength. Moreover, only ISWT was strongly correlated with higher HRQOL scores, including physical, mental, and kidney-specific domains, even after adjustment for age and sex. CONCLUSIONS: Exercise tolerance in PD patients was partially determined by age, sex, and SMI. Moreover, this is the first study to demonstrate the strong relationship between aerobic capacity and HRQOL in PD patients.
| Original language | English |
|---|---|
| Pages (from-to) | 66-73 |
| Number of pages | 8 |
| Journal | Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis |
| Volume | 39 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2019 Jan 1 |
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Keywords
- aerobic capacity
- dual-energy x-ray absorptiometry
- Incremental shuttle walking test
- muscle strength
- skeletal mass index
ASJC Scopus subject areas
- Nephrology
Cite this
Exercise Capacity and Association with Quality of Life in Peritoneal Dialysis Patients. / Uchiyama, Kiyotaka; Washida, Naoki; Muraoka, Kaori; Morimoto, Kohkichi; Kasai, Takahiro; Yamaki, Kentaro; Miyashita, Kazutoshi; Wakino, Shu; Itoh, Hiroshi.
In: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, Vol. 39, No. 1, 01.01.2019, p. 66-73.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Exercise Capacity and Association with Quality of Life in Peritoneal Dialysis Patients
AU - Uchiyama, Kiyotaka
AU - Washida, Naoki
AU - Muraoka, Kaori
AU - Morimoto, Kohkichi
AU - Kasai, Takahiro
AU - Yamaki, Kentaro
AU - Miyashita, Kazutoshi
AU - Wakino, Shu
AU - Itoh, Hiroshi
PY - 2019/1/1
Y1 - 2019/1/1
N2 - BACKGROUND: Muscle wasting, common and progressive in uremic patients, is associated with a high probability for morbidity, lower health-related quality of life (HRQOL), and mortality. However, exercise tolerance in peritoneal dialysis (PD) patients has not been fully elucidated. The aim of this study was to evaluate exercise capacity, its determinants, and its association with HRQOL in PD patients. METHODS: Outpatients treated with PD at Keio University Hospital from December 2016 to March 2018 were included in this single-center cross-sectional observational study. Exercise capacity was assessed by incremental shuttle walking test (ISWT) and handgrip and quadriceps strength. In addition to evaluation of PD-related parameters, HRQOL was assessed by the Kidney Disease Quality of Life-Short Form questionnaire. RESULTS: Among the 50 recruited PD outpatients, age and PD vintage were 63.8 ± 9.6 and 3.8 ± 2.8 years, respectively. Physical examination revealed ISWT of 312.0 ± 138.2 m, handgrip strength of 27.5 ± 6.9 kg, and quadriceps strength of 23.3 ± 10.0 kg. Multivariate analysis showed that younger age and male sex were significantly associated with higher ISWT and handgrip and quadriceps strength. Skeletal mass index (SMI) remained a significant predictor of handgrip and quadriceps strength. Moreover, only ISWT was strongly correlated with higher HRQOL scores, including physical, mental, and kidney-specific domains, even after adjustment for age and sex. CONCLUSIONS: Exercise tolerance in PD patients was partially determined by age, sex, and SMI. Moreover, this is the first study to demonstrate the strong relationship between aerobic capacity and HRQOL in PD patients.
AB - BACKGROUND: Muscle wasting, common and progressive in uremic patients, is associated with a high probability for morbidity, lower health-related quality of life (HRQOL), and mortality. However, exercise tolerance in peritoneal dialysis (PD) patients has not been fully elucidated. The aim of this study was to evaluate exercise capacity, its determinants, and its association with HRQOL in PD patients. METHODS: Outpatients treated with PD at Keio University Hospital from December 2016 to March 2018 were included in this single-center cross-sectional observational study. Exercise capacity was assessed by incremental shuttle walking test (ISWT) and handgrip and quadriceps strength. In addition to evaluation of PD-related parameters, HRQOL was assessed by the Kidney Disease Quality of Life-Short Form questionnaire. RESULTS: Among the 50 recruited PD outpatients, age and PD vintage were 63.8 ± 9.6 and 3.8 ± 2.8 years, respectively. Physical examination revealed ISWT of 312.0 ± 138.2 m, handgrip strength of 27.5 ± 6.9 kg, and quadriceps strength of 23.3 ± 10.0 kg. Multivariate analysis showed that younger age and male sex were significantly associated with higher ISWT and handgrip and quadriceps strength. Skeletal mass index (SMI) remained a significant predictor of handgrip and quadriceps strength. Moreover, only ISWT was strongly correlated with higher HRQOL scores, including physical, mental, and kidney-specific domains, even after adjustment for age and sex. CONCLUSIONS: Exercise tolerance in PD patients was partially determined by age, sex, and SMI. Moreover, this is the first study to demonstrate the strong relationship between aerobic capacity and HRQOL in PD patients.
KW - aerobic capacity
KW - dual-energy x-ray absorptiometry
KW - Incremental shuttle walking test
KW - muscle strength
KW - skeletal mass index
UR - http://www.scopus.com/inward/record.url?scp=85060569802&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85060569802&partnerID=8YFLogxK
U2 - 10.3747/pdi.2018.00075
DO - 10.3747/pdi.2018.00075
M3 - Article
C2 - 30478142
AN - SCOPUS:85060569802
VL - 39
SP - 66
EP - 73
JO - Peritoneal Dialysis International
JF - Peritoneal Dialysis International
SN - 0896-8608
IS - 1
ER -