Experimental and clinical studies on the intraperitoneal administration of cis-diamminedichloroplatinum (II) for peritoneal carcinomatosis caused by gastric cancers

Toshiharu Furukawa, Koichiro Kumai, Tetsuro Kubota, Shinobu Hirahata, Hiroyuki Shimizu, Hideo Matsui, Tetsuya Takahara, Ken Ichiro Aizawa, Sansei Shibata, Atsushi Shimada, Keiichi Yoshino, Kyuya Ishibiki, Masaki Kitajima

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9 Citations (Scopus)

Abstract

The effectiveness of the intraperitoneal administration of cis-diamminedichloroplatinum (II) (DDP) on peritoneal carcinomatosis caused by gastric cancers was evaluated. Seventeen patients were treated with one of three protocols, consisting of the intraperitoneal injection (ip) of DDP at doses of 70 and 110 mg/m2, with or without sodium thiosulfate (STS) rescue. The area under the curve (AUC) of DDP for sufficient anticancer activities against cultured human cell lines in vitro was estimated at 240 μg h/ml, which was equivalent to the AUC gained by 110 mg/m2 ip DDP in the clinical studies. The cytotoxic activity of DDP was reduced by approximately 50% with 100-fold STS in the AUC in the experimental studies. However, this was achieved only in urine, and not in either the peritoneal cavity or in plasma in the clinical studies. Three cases of a partial response against peritoneal carcinomatosis were seen from a total of four evaluable cases treated with 110 mg/m2 DDP, and no renal toxicities were observed in those treated with the STS rescue. The results of this study led us to conclude that high-dose ip DDP treatment combined with the STS rescue would be useful chemotherapy against peritoneal carcinomatosis caused by gastric cancers.

Original languageEnglish
Pages (from-to)298-306
Number of pages9
JournalSurgery today
Volume23
Issue number4
DOIs
Publication statusPublished - 1993 Apr 1

Keywords

  • cisplatin
  • gastric cancer
  • intraperitoneal chemotherapy
  • peritoneal carcinomatosis
  • sodium thiosulfate

ASJC Scopus subject areas

  • Surgery

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  • Cite this

    Furukawa, T., Kumai, K., Kubota, T., Hirahata, S., Shimizu, H., Matsui, H., Takahara, T., Aizawa, K. I., Shibata, S., Shimada, A., Yoshino, K., Ishibiki, K., & Kitajima, M. (1993). Experimental and clinical studies on the intraperitoneal administration of cis-diamminedichloroplatinum (II) for peritoneal carcinomatosis caused by gastric cancers. Surgery today, 23(4), 298-306. https://doi.org/10.1007/BF00309046