Experimental prediction of the wavelength-dependent path-length factor for optical intrinsic signal analysis

Koichiro Sakaguchi, Tomoya Tachibana, Shunsuke Furukawa, Takushige Katsura, Kyoko Yamazaki, Hideo Kawaguchi, Atsushi Maki, Eiji Okada

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Abstract

    Analysis of the optical intrinsic signal of an exposed cortex has been applied to measurement of functional brain activation. It is important for accurate measurement of concentration changes in oxygenated hemoglobin and deoxygenated hemoglobin to consider the wavelength dependence of the mean optical path lengths for the reflectance of cortical tissue. A method is proposed to experimentally estimate the wavelength dependence of the mean optical path length in cortical tissue from the multispectral reflectance of the exposed cortex without any additional instruments. The trend in the wavelength dependence of the mean optical path length estimated by the proposed method agrees with that estimated by the model-based prediction, whereas the magnitude of the wavelength dependence predicted by the proposed method is greater than that of the model-based prediction. The experimentally predicted mean optical path length minimizes the difference in the measured changes in the concentrations of the oxygenated hemoglobin and deoxygenated hemoglobin calculated from different wavelength pairs.

    Original languageEnglish
    Pages (from-to)2769-2777
    Number of pages9
    JournalApplied Optics
    Volume46
    Issue number14
    DOIs
    Publication statusPublished - 2007 May 10

    ASJC Scopus subject areas

    • Atomic and Molecular Physics, and Optics
    • Engineering (miscellaneous)
    • Electrical and Electronic Engineering

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  • Cite this

    Sakaguchi, K., Tachibana, T., Furukawa, S., Katsura, T., Yamazaki, K., Kawaguchi, H., Maki, A., & Okada, E. (2007). Experimental prediction of the wavelength-dependent path-length factor for optical intrinsic signal analysis. Applied Optics, 46(14), 2769-2777. https://doi.org/10.1364/AO.46.002769