Experimental stereotactic irradiation of normal rabbit lung: Computed tomographic analysis of radiation injury and the histopathological features

Takatsugu Kawase, Etsuo Kunieda, Hossain M. Deloar, Satoshi Seki, Akitomo Sugawara, Takanori Tsunoo, Eileen N. Ogawa, Akitoshi Ishizaka, Kaori Kameyama, Atsuya Takeda, Atsushi Kubo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose. The aim of this study was to establish an animal experimental model of pulmonary stereotactic irradiation and clarify the morphological patterns of pulmonary radiation injury with computed tomography and the histopathological features. Materials and methods. Tiny spherical regions in the lungs of seven anesthetized rabbits were irradiated stereotactically with a single fractional dose of 21-60 Gy. Subsequently, the irradiated lungs were observed biweekly with computed tomography (CT) for 24 weeks. Radiation injury of the lung was examined histopathologically in one specimen. Results. Localized hypodense changes were observed 7-15 weeks after irradiation in three rabbits irradiated with 60 Gy, and the findings persisted beyond that time. The electron density ratios in the lung fields obtained from the CT images were shown to be decreasing, corresponding to the hypodensity changes. No clear increased density opacity was observed in any rabbit in the 60-Gy irradiated group. Severe localized fibrotic change was observed in the histopathological specimens. Conclusion. Specific localized hypodensity changes were found in only three rabbits irradiated with 60 Gy, the highest dose we employed.

Original languageEnglish
Pages (from-to)453-461
Number of pages9
JournalRadiation Medicine - Medical Imaging and Radiation Oncology
Volume25
Issue number9
DOIs
Publication statusPublished - 2007 Nov

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radiation injuries
Radiation Injuries
rabbits
lungs
Rabbits
Lung
irradiation
tomography
Tomography
dosage
opacity
animals
Lung Injury
Animal Models
Electrons

Keywords

  • Computed tomography
  • Lung
  • Rabbit
  • Radiation injury
  • Stereotactic radiotherapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Experimental stereotactic irradiation of normal rabbit lung : Computed tomographic analysis of radiation injury and the histopathological features. / Kawase, Takatsugu; Kunieda, Etsuo; Deloar, Hossain M.; Seki, Satoshi; Sugawara, Akitomo; Tsunoo, Takanori; Ogawa, Eileen N.; Ishizaka, Akitoshi; Kameyama, Kaori; Takeda, Atsuya; Kubo, Atsushi.

In: Radiation Medicine - Medical Imaging and Radiation Oncology, Vol. 25, No. 9, 11.2007, p. 453-461.

Research output: Contribution to journalArticle

Kawase, Takatsugu ; Kunieda, Etsuo ; Deloar, Hossain M. ; Seki, Satoshi ; Sugawara, Akitomo ; Tsunoo, Takanori ; Ogawa, Eileen N. ; Ishizaka, Akitoshi ; Kameyama, Kaori ; Takeda, Atsuya ; Kubo, Atsushi. / Experimental stereotactic irradiation of normal rabbit lung : Computed tomographic analysis of radiation injury and the histopathological features. In: Radiation Medicine - Medical Imaging and Radiation Oncology. 2007 ; Vol. 25, No. 9. pp. 453-461.
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