Experimental study on the significance of serum alcohol dehydrogenase activity

Research output: Contribution to journalArticle

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Abstract

Clinical usefulness of serum alcohol dehydrogenase (ADH) activity was studied by experimental animals, comparing to the activities of glutamate pyruvate transaminase (GPT) and glutamate dehydrogenase (GLDH) in serum. ADH was shown to be distributed predominantly in zone 3 of hepatic acinus in rat by immunohistochemical method. Serum ADH activity was markedly increased when bromobenzene was administered, reflecting zone 3 hepatic necrosis. However, ally lalcohol administration resulted in slight increase of serum ADH activity compared with elevation of other enzymes. Furthermore, serum ADH activity increased preceding GLDH in early phase after administration of bromobenzene. The results of experimental model with acute alcohol administration or hypoxia induced liver damage also suggested that ADH is a sensitive indicator of hepatic zone 3 damage.

Original languageEnglish
Pages (from-to)2074-2081
Number of pages8
JournalNippon Shokakibyo Gakkai Zasshi
Volume82
Issue number9
DOIs
Publication statusPublished - 1985

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Alcohol Dehydrogenase
Serum
Glutamate Dehydrogenase
Liver
Transaminases
Pyruvic Acid
Glutamic Acid
Theoretical Models
Necrosis
Alcohols
Enzymes

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Experimental study on the significance of serum alcohol dehydrogenase activity. / Kato, Shinzo.

In: Nippon Shokakibyo Gakkai Zasshi, Vol. 82, No. 9, 1985, p. 2074-2081.

Research output: Contribution to journalArticle

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