Experimental validation of Monte Carlo and finite-element methods for the estimation of the optical path length in inhomogeneous tissue

Eiji Okada, Martin Schweiger, Simon R. Arridge, Michael Firbank, David T. Delpy

    Research output: Contribution to journalArticle

    31 Citations (Scopus)

    Abstract

    To validate models of light propagation in biological tissue, experiments to measure the mean time of flight have been carried out on several solid cylindrical layered phantoms. The optical properties of the inner cylinders of the phantoms were close to those of adult brain white matter, whereas a range of scattering or absorption coefficients was chosen for the outer layer. Experimental results for the mean optical path length have been compared with the predictions of both an exact Monte Carlo (MC) model and a diffusion equation, with two differing boundary conditions implemented in a finite-element method (FEM). The MC and experimental results are in good agreement despite poor statistics for large fiber spacings, whereas good agreement with the FEM prediction requires a careful choice of proper boundary conditions.

    Original languageEnglish
    Pages (from-to)3362-3371
    Number of pages10
    JournalApplied Optics
    Volume35
    Issue number19
    DOIs
    Publication statusPublished - 1996 Jul 1

    Keywords

    • Finite-element method
    • Light propagation
    • Monte Carlo method
    • Time-of-flight measurement

    ASJC Scopus subject areas

    • Atomic and Molecular Physics, and Optics
    • Engineering (miscellaneous)
    • Electrical and Electronic Engineering

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