Exploring personality traits related to dopamine D2/3 receptor availability in striatal subregions of humans

Fernando Caravaggio, Gagan Fervaha, Jun Ku Chung, Philip Gerretsen, Shinichiro Nakajima, Eric Plitman, Yusuke Iwata, Alan Wilson, Ariel Graff-Guerrero

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

While several studies have examined how particular personality traits are related to dopamine D2/3 receptor (D2/3R) availability in the striatum of humans, few studies have reported how multiple traits measured in the same persons are differentially related to D2/3R availability in different striatal sub-regions. We examined how personality traits measured with the Karolinska Scales of Personality are related to striatal D2/3R availability measured with [11C]-raclopride in 30 healthy humans. Based on previous the literature, five personality traits were hypothesized to be most likely related to D2/3R availability: impulsiveness, monotony avoidance, detachment, social desirability, and socialization. We found self-reported impulsiveness was negatively correlated with D2/3R availability in the ventral striatum and globus pallidus. After controlling for age and gender, monotony avoidance was also negatively correlated with D2/3R availability in the ventral striatum and globus pallidus. Socialization was positively correlated with D2/3R availability in the ventral striatum and putamen. After controlling for age and gender, the relationship between socialization and D2/3R availability in these regions survived correction for multiple comparisons (p-threshold=.003). Thus, within the same persons, different personality traits are differentially related to in vivo D2/3R availability in different striatal sub-regions.

Original languageEnglish
Pages (from-to)644-652
Number of pages9
JournalEuropean Neuropsychopharmacology
Volume26
Issue number4
DOIs
Publication statusPublished - 2016 Apr 1
Externally publishedYes

Fingerprint

Corpus Striatum
Dopamine D2 Receptors
Personality
Socialization
Globus Pallidus
Raclopride
Social Desirability
Putamen
Ventral Striatum

Keywords

  • DR
  • Dopamine
  • Personality
  • PET
  • [C]-raclopride

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

Cite this

Exploring personality traits related to dopamine D2/3 receptor availability in striatal subregions of humans. / Caravaggio, Fernando; Fervaha, Gagan; Chung, Jun Ku; Gerretsen, Philip; Nakajima, Shinichiro; Plitman, Eric; Iwata, Yusuke; Wilson, Alan; Graff-Guerrero, Ariel.

In: European Neuropsychopharmacology, Vol. 26, No. 4, 01.04.2016, p. 644-652.

Research output: Contribution to journalArticle

Caravaggio, F, Fervaha, G, Chung, JK, Gerretsen, P, Nakajima, S, Plitman, E, Iwata, Y, Wilson, A & Graff-Guerrero, A 2016, 'Exploring personality traits related to dopamine D2/3 receptor availability in striatal subregions of humans', European Neuropsychopharmacology, vol. 26, no. 4, pp. 644-652. https://doi.org/10.1016/j.euroneuro.2016.02.010
Caravaggio, Fernando ; Fervaha, Gagan ; Chung, Jun Ku ; Gerretsen, Philip ; Nakajima, Shinichiro ; Plitman, Eric ; Iwata, Yusuke ; Wilson, Alan ; Graff-Guerrero, Ariel. / Exploring personality traits related to dopamine D2/3 receptor availability in striatal subregions of humans. In: European Neuropsychopharmacology. 2016 ; Vol. 26, No. 4. pp. 644-652.
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