Exploring personality traits related to dopamine D2/3 receptor availability in striatal subregions of humans

Fernando Caravaggio, Gagan Fervaha, Jun Ku Chung, Philip Gerretsen, Shinichiro Nakajima, Eric Plitman, Yusuke Iwata, Alan Wilson, Ariel Graff-Guerrero

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

While several studies have examined how particular personality traits are related to dopamine D2/3 receptor (D2/3R) availability in the striatum of humans, few studies have reported how multiple traits measured in the same persons are differentially related to D2/3R availability in different striatal sub-regions. We examined how personality traits measured with the Karolinska Scales of Personality are related to striatal D2/3R availability measured with [11C]-raclopride in 30 healthy humans. Based on previous the literature, five personality traits were hypothesized to be most likely related to D2/3R availability: impulsiveness, monotony avoidance, detachment, social desirability, and socialization. We found self-reported impulsiveness was negatively correlated with D2/3R availability in the ventral striatum and globus pallidus. After controlling for age and gender, monotony avoidance was also negatively correlated with D2/3R availability in the ventral striatum and globus pallidus. Socialization was positively correlated with D2/3R availability in the ventral striatum and putamen. After controlling for age and gender, the relationship between socialization and D2/3R availability in these regions survived correction for multiple comparisons (p-threshold=.003). Thus, within the same persons, different personality traits are differentially related to in vivo D2/3R availability in different striatal sub-regions.

Original languageEnglish
Pages (from-to)644-652
Number of pages9
JournalEuropean Neuropsychopharmacology
Volume26
Issue number4
DOIs
Publication statusPublished - 2016 Apr 1
Externally publishedYes

Keywords

  • DR
  • Dopamine
  • Personality
  • PET
  • [C]-raclopride

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

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    Caravaggio, F., Fervaha, G., Chung, J. K., Gerretsen, P., Nakajima, S., Plitman, E., Iwata, Y., Wilson, A., & Graff-Guerrero, A. (2016). Exploring personality traits related to dopamine D2/3 receptor availability in striatal subregions of humans. European Neuropsychopharmacology, 26(4), 644-652. https://doi.org/10.1016/j.euroneuro.2016.02.010