TY - JOUR
T1 - Exploring personality traits related to dopamine D2/3 receptor availability in striatal subregions of humans
AU - Caravaggio, Fernando
AU - Fervaha, Gagan
AU - Chung, Jun Ku
AU - Gerretsen, Philip
AU - Nakajima, Shinichiro
AU - Plitman, Eric
AU - Iwata, Yusuke
AU - Wilson, Alan
AU - Graff-Guerrero, Ariel
N1 - Funding Information:
This study was funded by Canadian Institutes of Health Research ( MOP-114989 ) and U.S. National Institute of Health ( RO1MH084886-01A2 ).
Funding Information:
This study was funded by Canadian Institutes of Health Research (MOP-114989) and U.S. National Institute of Health (RO1MH084886-01A2). These organizations had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.
Funding Information:
Dr. Nakajima reports having received Grants from Japan Society for the Promotion of Science and Inokashira Hospital Research Fund and speaker׳s honoraria from GlaxoSmith Kline, Janssen Pharmaceutical, Pfizer, and Yoshitomiyakuhin within the past 3 years. Dr. Graff-Guerrero currently receives research support from the following external funding agencies: Canadian Institutes of Health Research, the U.S. National Institute of Health, and the Mexico Instituto de Ciencia y Tecnologıa para la Capital del Conocimiento en el Distrito Federal (ICyTDF). He has also received professional services compensation from Abbott Laboratories, Gedeon-Richter Plc, and Lundbeck; Grant support from Janssen; and speaker compensation from Eli Lilly. The other authors report no biomedical financial interests or potential conflicts of interest relevant to the current study.
Publisher Copyright:
© 2016 Elsevier B.V. and ECNP.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - While several studies have examined how particular personality traits are related to dopamine D2/3 receptor (D2/3R) availability in the striatum of humans, few studies have reported how multiple traits measured in the same persons are differentially related to D2/3R availability in different striatal sub-regions. We examined how personality traits measured with the Karolinska Scales of Personality are related to striatal D2/3R availability measured with [11C]-raclopride in 30 healthy humans. Based on previous the literature, five personality traits were hypothesized to be most likely related to D2/3R availability: impulsiveness, monotony avoidance, detachment, social desirability, and socialization. We found self-reported impulsiveness was negatively correlated with D2/3R availability in the ventral striatum and globus pallidus. After controlling for age and gender, monotony avoidance was also negatively correlated with D2/3R availability in the ventral striatum and globus pallidus. Socialization was positively correlated with D2/3R availability in the ventral striatum and putamen. After controlling for age and gender, the relationship between socialization and D2/3R availability in these regions survived correction for multiple comparisons (p-threshold=.003). Thus, within the same persons, different personality traits are differentially related to in vivo D2/3R availability in different striatal sub-regions.
AB - While several studies have examined how particular personality traits are related to dopamine D2/3 receptor (D2/3R) availability in the striatum of humans, few studies have reported how multiple traits measured in the same persons are differentially related to D2/3R availability in different striatal sub-regions. We examined how personality traits measured with the Karolinska Scales of Personality are related to striatal D2/3R availability measured with [11C]-raclopride in 30 healthy humans. Based on previous the literature, five personality traits were hypothesized to be most likely related to D2/3R availability: impulsiveness, monotony avoidance, detachment, social desirability, and socialization. We found self-reported impulsiveness was negatively correlated with D2/3R availability in the ventral striatum and globus pallidus. After controlling for age and gender, monotony avoidance was also negatively correlated with D2/3R availability in the ventral striatum and globus pallidus. Socialization was positively correlated with D2/3R availability in the ventral striatum and putamen. After controlling for age and gender, the relationship between socialization and D2/3R availability in these regions survived correction for multiple comparisons (p-threshold=.003). Thus, within the same persons, different personality traits are differentially related to in vivo D2/3R availability in different striatal sub-regions.
KW - DR
KW - Dopamine
KW - PET
KW - Personality
KW - [C]-raclopride
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U2 - 10.1016/j.euroneuro.2016.02.010
DO - 10.1016/j.euroneuro.2016.02.010
M3 - Article
C2 - 26944295
AN - SCOPUS:84960830508
SN - 0924-977X
VL - 26
SP - 644
EP - 652
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
IS - 4
ER -
