Exploring the glycan interaction in vivo: Future prospects of neo-glycoproteins for diagnostics

Akihiro Ogura, Almira Kurbangalieva, Katsunori Tanaka

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Herein the biodistributions and in vivo kinetics of chemically prepared neoglycoproteins are reviewed. Chemical methods can be used to conjugate various mono- and oligosaccharides onto a protein surface. The kinetics and organ-specific accumulation profiles of these glycoconjugates, which are introduced through intravenous injections, have been analyzed using conventional dissection studies as well as noninvasive methods such as single photon emission computed tomography, positron emission tomography and fluorescence imaging. These studies suggest that glycan-dependent protein distribution kinetics may be useful for pharmacological and diagnostic applications.

Original languageEnglish
Pages (from-to)804-812
Number of pages9
JournalGlycobiology
Volume26
Issue number8
DOIs
Publication statusPublished - 2016 Aug 1
Externally publishedYes

Keywords

  • albumin
  • in vivo imaging
  • N-glycans
  • neoglycoprotein
  • tumor targeting

ASJC Scopus subject areas

  • Biochemistry

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