Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease.

Masataka Kawai, Yoko Ogawa, Shigeto Shimmura, Shigeki Ota, Takanori Suzuki, Naoshi Kawamura, Masataka Kuwana, Yutaka Kawakami, Kazuo Tsubota

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Abstract

Aging is commonly defined as the accumulation of diverse deleterious changes in cells and tissues with advancing age. To investigate whether aging changes are involved in the lacrimal glands of chronic graft-versus-host disease (cGVHD) model mice, we obtained the specimens from cGVHD model mice, untreated aged and young mice, and examined by histopathology, and immunoblotting. Oxidative stress markers, 8-OHdG, 4-HNE, and hexonoyl lesion (HEL), and other aging markers, p16 and p38, were used to assess the samples. The infiltrating mononuclear cells and endothelia of capillaries in the cGVHD and aged mice expressed the oxidative stress markers and other aging markers, but not in the young mice. Histological changes and the expression of aging markers in the samples from cGVHD mice exhibited similar features to those in aging mice. These results suggest that changes that typically appear with advanced age occur earlier in the lives of mice with lacrimal gland cGVHD.

Original languageEnglish
Pages (from-to)2455
Number of pages1
JournalScientific Reports
Volume3
Publication statusPublished - 2013

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Lacrimal Apparatus
Graft vs Host Disease
Oxidative Stress
Vascular Endothelium
Immunoblotting

ASJC Scopus subject areas

  • General

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Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease. / Kawai, Masataka; Ogawa, Yoko; Shimmura, Shigeto; Ota, Shigeki; Suzuki, Takanori; Kawamura, Naoshi; Kuwana, Masataka; Kawakami, Yutaka; Tsubota, Kazuo.

In: Scientific Reports, Vol. 3, 2013, p. 2455.

Research output: Contribution to journalArticle

Kawai, Masataka ; Ogawa, Yoko ; Shimmura, Shigeto ; Ota, Shigeki ; Suzuki, Takanori ; Kawamura, Naoshi ; Kuwana, Masataka ; Kawakami, Yutaka ; Tsubota, Kazuo. / Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease. In: Scientific Reports. 2013 ; Vol. 3. pp. 2455.
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