Expression and localization of aquaporin-4 in sensory ganglia

Jungo Kato, Yoshiki Takai, Mariko Kato Hayashi, Yasuhiro Kato, Manami Tanaka, Yoshiro Sohma, Yoichiro Abe, Masato Yasui

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Aquaporin-4 (AQP4) is a water channel protein that is predominantly expressed in astrocytes in the CNS. The rapid water flux through AQP4 may contribute to electrolyte/water homeostasis and may support neuronal activities in the CNS. On the other hand, little is known about the expression of AQP4 in the peripheral nervous system (PNS). Using AQP4-/- mice as a negative control, we demonstrated that AQP4 is also expressed in sensory ganglia, such as trigeminal ganglia and dorsal root ganglia in the PNS. Immunohistochemistry revealed that AQP4 is exclusively localized to satellite glial cells (SGCs) surrounding the cell bodies of the primary afferent sensory neurons in the sensory ganglia. Biochemical analyses revealed that the expression levels of AQP4 in sensory ganglia were considerably lower than those in astrocytes in the CNS. Consistently, behavioral analyses did not show any significant difference in terms of mechanical and cold sensitivity between wild type and AQP4-/- mice. Overall, although the pathophysiological relevance of AQP4 in somatosensory perception remains unclear, our findings provide new insight into the involvement of water homeostasis in the peripheral sensory system.

Original languageEnglish
Pages (from-to)562-567
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume451
Issue number4
DOIs
Publication statusPublished - 2014 Sep 5

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Keywords

  • AQP4
  • Satellite glial cells
  • Sensory ganglia
  • The peripheral nervous system
  • Water homeostasis

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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