Expression in Escherichia coli of a new multidrug efflux pump, MexXY, from Pseudomonas aeruginosa

Tomoyuki Mine, Yuji Morita, Atsuko Kataoka, Tohru Mizushima, Tomofusa Tsuchiya

Research output: Contribution to journalArticle

210 Citations (Scopus)

Abstract

Two new genes (mexXY) similar to mexAB, mexCD, and mexEF and mediating multidrug resistance were cloned from the chromosome of Pseudomonas aeruginosa. Elevated ethidium extrusion was observed with Escherichia coli cells harboring the plasmid carrying mexXY. This MexXY system confers higher resistance to fluoroquinolones than the MexAB and MexCD systems, and E. coli TolC or P. aeruginosa OprM is necessary for the function of the MexXY system.

Original languageEnglish
Pages (from-to)415-417
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume43
Issue number2
DOIs
Publication statusPublished - 1999 Feb

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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