TY - JOUR
T1 - Expression in Escherichia coli of a new multidrug efflux pump, MexXY, from Pseudomonas aeruginosa
AU - Mine, Tomoyuki
AU - Morita, Yuji
AU - Kataoka, Atsuko
AU - Mizushima, Tohru
AU - Tsuchiya, Tomofusa
PY - 1999/2
Y1 - 1999/2
N2 - Two new genes (mexXY) similar to mexAB, mexCD, and mexEF and mediating multidrug resistance were cloned from the chromosome of Pseudomonas aeruginosa. Elevated ethidium extrusion was observed with Escherichia coli cells harboring the plasmid carrying mexXY. This MexXY system confers higher resistance to fluoroquinolones than the MexAB and MexCD systems, and E. coli TolC or P. aeruginosa OprM is necessary for the function of the MexXY system.
AB - Two new genes (mexXY) similar to mexAB, mexCD, and mexEF and mediating multidrug resistance were cloned from the chromosome of Pseudomonas aeruginosa. Elevated ethidium extrusion was observed with Escherichia coli cells harboring the plasmid carrying mexXY. This MexXY system confers higher resistance to fluoroquinolones than the MexAB and MexCD systems, and E. coli TolC or P. aeruginosa OprM is necessary for the function of the MexXY system.
UR - http://www.scopus.com/inward/record.url?scp=0032994954&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032994954&partnerID=8YFLogxK
U2 - 10.1128/aac.43.2.415
DO - 10.1128/aac.43.2.415
M3 - Article
C2 - 9925549
AN - SCOPUS:0032994954
SN - 0066-4804
VL - 43
SP - 415
EP - 417
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 2
ER -
