Expression mechanism of human uterine endometrial cancer-specific fucosylated carbohydrate chains: Aberrant α 1→4 fucosyltransferases in uterine endometrial cancer-derived cell lines with type I carbohydrate chain

K. Kubushiro, K. Tsukazaki, Y. Sakuma, Y. Akiba, M. Sakayori, R. Aoki, S. Yazawa, S. Nozawa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cells of uterine endometrial cancer cell line SNG-II were classified into two groups according to their reactivity with anti-uterine endometrial cancer monoclonal antibody (MSN-1), whose recognition antigen is mainly the Lewis(b) antigens; those that strongly reacted with MSN-1 (SNG-S group) and those that weakly reacted with it (SNG-W group). The SNG-S showed a higher activity of α 1→4-fucosyltransferase activity than that of the SNG-W. The expression of Lewisb antigen was stronger in the SNG-S than that in the SNG-W. Therefore, the expression of uterine endometrial cancer-specific fucosylated carbohydrate could be mainly controlled by α-fucosyltransferase activities.

Original languageEnglish
Pages (from-to)93-97
Number of pages5
JournalInternational journal of oncology
Volume6
Issue number1
Publication statusPublished - 1995 Jan 1

Keywords

  • MSN-1
  • blood group antigen
  • expression mechanism
  • fucosyltransferase
  • uterine endometrial cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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