Expression mechanism of human uterine endometrial cancer-specific fucosylated carbohydrate chains: Aberrant α 1→4 fucosyltransferases in uterine endometrial cancer-derived cell lines with type I carbohydrate chain

K. Kubushiro; K. Tsukazaki; Y. Sakuma; Y. Akiba; M. Sakayori; R. Aoki; S. Yazawa; S. Nozawa

Expression mechanism of human uterine endometrial cancer-specific fucosylated carbohydrate chains: Aberrant α 1→4 fucosyltransferases in uterine endometrial cancer-derived cell lines with type I carbohydrate chain

K. Kubushiro, K. Tsukazaki, Y. Sakuma, Y. Akiba, M. Sakayori, R. Aoki, S. Yazawa, S. Nozawa

Department of Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Cells of uterine endometrial cancer cell line SNG-II were classified into two groups according to their reactivity with anti-uterine endometrial cancer monoclonal antibody (MSN-1), whose recognition antigen is mainly the Lewis(b) antigens; those that strongly reacted with MSN-1 (SNG-S group) and those that weakly reacted with it (SNG-W group). The SNG-S showed a higher activity of α 1→4-fucosyltransferase activity than that of the SNG-W. The expression of Lewis^b antigen was stronger in the SNG-S than that in the SNG-W. Therefore, the expression of uterine endometrial cancer-specific fucosylated carbohydrate could be mainly controlled by α-fucosyltransferase activities.

Original language	English
Pages (from-to)	93-97
Number of pages	5
Journal	International journal of oncology
Volume	6
Issue number	1
Publication status	Published - 1995 Jan 1

Keywords

MSN-1
blood group antigen
expression mechanism
fucosyltransferase
uterine endometrial cancer

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Kubushiro, K., Tsukazaki, K., Sakuma, Y., Akiba, Y., Sakayori, M., Aoki, R., Yazawa, S., & Nozawa, S. (1995). Expression mechanism of human uterine endometrial cancer-specific fucosylated carbohydrate chains: Aberrant α 1→4 fucosyltransferases in uterine endometrial cancer-derived cell lines with type I carbohydrate chain. International journal of oncology, 6(1), 93-97.

Expression mechanism of human uterine endometrial cancer-specific fucosylated carbohydrate chains : Aberrant α 1→4 fucosyltransferases in uterine endometrial cancer-derived cell lines with type I carbohydrate chain. / Kubushiro, K.; Tsukazaki, K.; Sakuma, Y. et al.

In: International journal of oncology, Vol. 6, No. 1, 01.01.1995, p. 93-97.

Research output: Contribution to journal › Article › peer-review

Kubushiro, K, Tsukazaki, K, Sakuma, Y, Akiba, Y, Sakayori, M, Aoki, R, Yazawa, S & Nozawa, S 1995, 'Expression mechanism of human uterine endometrial cancer-specific fucosylated carbohydrate chains: Aberrant α 1→4 fucosyltransferases in uterine endometrial cancer-derived cell lines with type I carbohydrate chain', International journal of oncology, vol. 6, no. 1, pp. 93-97.

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abstract = "Cells of uterine endometrial cancer cell line SNG-II were classified into two groups according to their reactivity with anti-uterine endometrial cancer monoclonal antibody (MSN-1), whose recognition antigen is mainly the Lewis(b) antigens; those that strongly reacted with MSN-1 (SNG-S group) and those that weakly reacted with it (SNG-W group). The SNG-S showed a higher activity of α 1→4-fucosyltransferase activity than that of the SNG-W. The expression of Lewisb antigen was stronger in the SNG-S than that in the SNG-W. Therefore, the expression of uterine endometrial cancer-specific fucosylated carbohydrate could be mainly controlled by α-fucosyltransferase activities.",

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AU - Kubushiro, K.

AU - Tsukazaki, K.

AU - Sakuma, Y.

AU - Akiba, Y.

AU - Sakayori, M.

AU - Aoki, R.

AU - Yazawa, S.

AU - Nozawa, S.

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AB - Cells of uterine endometrial cancer cell line SNG-II were classified into two groups according to their reactivity with anti-uterine endometrial cancer monoclonal antibody (MSN-1), whose recognition antigen is mainly the Lewis(b) antigens; those that strongly reacted with MSN-1 (SNG-S group) and those that weakly reacted with it (SNG-W group). The SNG-S showed a higher activity of α 1→4-fucosyltransferase activity than that of the SNG-W. The expression of Lewisb antigen was stronger in the SNG-S than that in the SNG-W. Therefore, the expression of uterine endometrial cancer-specific fucosylated carbohydrate could be mainly controlled by α-fucosyltransferase activities.

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Expression mechanism of human uterine endometrial cancer-specific fucosylated carbohydrate chains: Aberrant α 1→4 fucosyltransferases in uterine endometrial cancer-derived cell lines with type I carbohydrate chain

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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