Expression of atrial natriuretic factor gene in hearts from neonates of spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats

H. Arai, K. Nakao, Y. Saito, A. Sugawara, T. Yamada, Hiroshi Itoh, M. Mukoyama, K. Hosoda, G. Shirakami, N. Morii, S. Shiono, H. Ohkubo, S. Nakanishi, H. Imura

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Abstract

In order to further elucidate the expression of the atrial natriuretic factor (ANF) gene in spontaneously hypertensive rats (SHR) and the substrain, stroke-prone SHR (SHRSP), ANF messenger (m)RNA levels in the atrium and in the ventricle were measured in neonates of SHR and SHRSP and were compared with those in control Wistar-Kyoto rats (WKY). The levels of ANF mRNA in ventricles of the three strains reached approximately 7% of those in atria; however, no significant difference was observed in atrial and ventricular ANF mRNA levels among the three strains. These results demonstrate that the expression of the ANF gene in hearts from neonates of WKY, SHR and SHRSP is similar among the three strains.

Original languageEnglish
JournalJournal of Hypertension
Volume6
Issue numberSUPPL. 4
Publication statusPublished - 1988
Externally publishedYes

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Atrial Natriuretic Factor
Inbred SHR Rats
Stroke
Inbred WKY Rats
Messenger RNA
Genes

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine

Cite this

Expression of atrial natriuretic factor gene in hearts from neonates of spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats. / Arai, H.; Nakao, K.; Saito, Y.; Sugawara, A.; Yamada, T.; Itoh, Hiroshi; Mukoyama, M.; Hosoda, K.; Shirakami, G.; Morii, N.; Shiono, S.; Ohkubo, H.; Nakanishi, S.; Imura, H.

In: Journal of Hypertension, Vol. 6, No. SUPPL. 4, 1988.

Research output: Contribution to journalArticle

Arai, H, Nakao, K, Saito, Y, Sugawara, A, Yamada, T, Itoh, H, Mukoyama, M, Hosoda, K, Shirakami, G, Morii, N, Shiono, S, Ohkubo, H, Nakanishi, S & Imura, H 1988, 'Expression of atrial natriuretic factor gene in hearts from neonates of spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats', Journal of Hypertension, vol. 6, no. SUPPL. 4.
Arai, H. ; Nakao, K. ; Saito, Y. ; Sugawara, A. ; Yamada, T. ; Itoh, Hiroshi ; Mukoyama, M. ; Hosoda, K. ; Shirakami, G. ; Morii, N. ; Shiono, S. ; Ohkubo, H. ; Nakanishi, S. ; Imura, H. / Expression of atrial natriuretic factor gene in hearts from neonates of spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats. In: Journal of Hypertension. 1988 ; Vol. 6, No. SUPPL. 4.
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abstract = "In order to further elucidate the expression of the atrial natriuretic factor (ANF) gene in spontaneously hypertensive rats (SHR) and the substrain, stroke-prone SHR (SHRSP), ANF messenger (m)RNA levels in the atrium and in the ventricle were measured in neonates of SHR and SHRSP and were compared with those in control Wistar-Kyoto rats (WKY). The levels of ANF mRNA in ventricles of the three strains reached approximately 7{\%} of those in atria; however, no significant difference was observed in atrial and ventricular ANF mRNA levels among the three strains. These results demonstrate that the expression of the ANF gene in hearts from neonates of WKY, SHR and SHRSP is similar among the three strains.",
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T1 - Expression of atrial natriuretic factor gene in hearts from neonates of spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats

AU - Arai, H.

AU - Nakao, K.

AU - Saito, Y.

AU - Sugawara, A.

AU - Yamada, T.

AU - Itoh, Hiroshi

AU - Mukoyama, M.

AU - Hosoda, K.

AU - Shirakami, G.

AU - Morii, N.

AU - Shiono, S.

AU - Ohkubo, H.

AU - Nakanishi, S.

AU - Imura, H.

PY - 1988

Y1 - 1988

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