Expression of atrial natriuretic factor gene in hearts from neonates of spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats

Hiroshi Arai, Kazuwa Nakao, Yoshihiko Saito, Akira Sugawara, Takayuki Yamada, Hiroshi Itoh, Masashi Mukoyama, Kiminori Hosoda, Gotaro Shirakami, Narito Morii, Shozo Shiono, Hiroaki Ohkubo, Shigeteda Nakanishi, Hiroo Imura

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2 Citations (Scopus)

Abstract

In order to further elucidate the expression of the atrial natriuretic factor (ANF) gene in spontaneously hypertensive rats (SHR) and the substrain, stroke-prone SHR (SHRSP), ANF messenger (m)RNA levels in the atrium and in the ventricle were measured in neonates of SHR and SHRSP and were compared with those in control Wistar-Kyoto rats (WKY). The levels of ANF mRNA in ventricles of the three strains reached approximately 7% of those in atria; however, no significant difference was observed in atrial and ventricular ANF mRNA levels among the three strains. These results demonstrate that the expression of the ANF gene in hearts from neonates of WKY, SHR and SHRSP is similar among the three strains.

Original languageEnglish
Pages (from-to)S276-S278
JournalJournal of Hypertension, Supplement
Volume6
Issue number4
Publication statusPublished - 1988 Dec
Externally publishedYes

Keywords

  • Atrial natriuretic polypeptide
  • Gene expression
  • Messenger RNA
  • Neonate
  • Spontaneously hypertensive rats
  • Ventricle

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Arai, H., Nakao, K., Saito, Y., Sugawara, A., Yamada, T., Itoh, H., Mukoyama, M., Hosoda, K., Shirakami, G., Morii, N., Shiono, S., Ohkubo, H., Nakanishi, S., & Imura, H. (1988). Expression of atrial natriuretic factor gene in hearts from neonates of spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats. Journal of Hypertension, Supplement, 6(4), S276-S278.