Expression of basic fibroblast growth factor is associated with a good outcome in patients with squamous cell carcinoma of the esophagus

Takeshi Nakamura, Soji Ozawa, Yuukou Kitagawa, Chih Horng Shih, Masakazu Ueda, Masaki Kitajima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Angiogenesis is an essential step in tumor growth and metastasis, but rather than being controlled by means of a simple mechanism, the control of tumor angiogenesis may be mediated by several angiogenic factors. We investigated the expression of basic fibroblast growth factor (b-FGF) and platelet-derived endothelial cell growth factor (PD-ECGF) in squamous cell carcinoma of the esophagus in order to clarify the mechanism of angiogenesis. Expression of b-FGF and PD-ECGF was immunohistochemically investigated in tissue specimens from the tumors of 79 patients with squamous cell carcinoma of the esophagus who underwent curative esophagectomy without preoperative chemotherapy or radiation therapy, and the relationship between expression of b-FGF/PD-ECGF, microvessel density (MVD), and clinicopathological background factors was assessed. Tumor cells that expressed b-FGF were found in 41 patients (51.9%), and tumor cells that expressed PD-ECGF were found in 57 patients (72.2%). Although the mean vascular density (47.9/mm2) of b-FGF-positive tumors was significantly lower than that (67.2/mm2) of b-FGF-negative tumors (p=0.014), the difference between the 56.0/mm2 in PD-ECGF-positive tumors and 60.3/mm2 in PD-ECGF-negative tumors was not significant. Although the survival rate of patients with b-FGF-positive tumors was significantly higher than those with b-FGF-negative tumors (p=0.033), there was no significant difference between the survival rates of patients with PD-ECGF-positive and -negative tumors (p=0.580). Expression of b-FGF may be associated with promotion of angiogenesis and a good prognostic factor in squamous cell carcinoma of the esophagus.

Original languageEnglish
Pages (from-to)617-623
Number of pages7
JournalOncology Reports
Volume14
Issue number3
Publication statusPublished - 2005 Sep

Fingerprint

Fibroblast Growth Factor 2
Esophagus
Squamous Cell Carcinoma
Thymidine Phosphorylase
Neoplasms
Survival Rate
Esophagectomy
Angiogenesis Inducing Agents
Microvessels
Blood Vessels
Radiotherapy
Neoplasm Metastasis
Drug Therapy

Keywords

  • Basic-fibroblast growth factor
  • Platelet-derived endothelial cell growth factor
  • Prognosis
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Expression of basic fibroblast growth factor is associated with a good outcome in patients with squamous cell carcinoma of the esophagus. / Nakamura, Takeshi; Ozawa, Soji; Kitagawa, Yuukou; Shih, Chih Horng; Ueda, Masakazu; Kitajima, Masaki.

In: Oncology Reports, Vol. 14, No. 3, 09.2005, p. 617-623.

Research output: Contribution to journalArticle

Nakamura, Takeshi ; Ozawa, Soji ; Kitagawa, Yuukou ; Shih, Chih Horng ; Ueda, Masakazu ; Kitajima, Masaki. / Expression of basic fibroblast growth factor is associated with a good outcome in patients with squamous cell carcinoma of the esophagus. In: Oncology Reports. 2005 ; Vol. 14, No. 3. pp. 617-623.
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