Expression of c-kit receptor (CD 117) and CD34 in leukemic cells

Kazuo Muroi, Mitsuru Nakamurat, Youichi Amemiya, Toshio Suda, Yasusada Miura

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26 Citations (Scopus)

Abstract

The expression of c-kit receptor (c-kit R; CD117) and CD34 was examined in acute myeloid leukemia (AML), acute lymphoid leukemia (ALL), chronic myeloid leukemia (CML) in blastic transformation (BT), and myelofibrosis (MF) in myeloid BT. In myeloid leukemia including AML, CML-myeloid BT and MF-myeloid BT, both c-kit R and CD34 were expressed synchronously, while in lymphoid leukemia including ALL and CML-lymphoid BT, only CD34 was highly expressed. A close correlation between c-kit R and CD33 expression and an inverse correlation between c-kit R and CD 19 expression were observed when all of the myeloid plus lymphoid leukemia cells were analysed. There was a close correlation between c-kit R and CD34 expression in the myeloid leukemia cells, c-kit R expression may be associated with myeloid phenotypes of leukemic cells and may be useful for the diagnosis of myeloid leukemia. The literature of c-kit R expression in leukemic cells is reviewed here and the comparison of c-kit R and CD34 expression in normal hematopoietic progenitor cells with those on the leukemic counterparts was discussed.

Original languageEnglish
Pages (from-to)297-305
Number of pages9
JournalLeukemia and Lymphoma
Volume16
Issue number3-4
DOIs
Publication statusPublished - 1995 Jan 1

Keywords

  • Acute lymphoid leukemia
  • Acute myeloid leukemia
  • C-kit receptor
  • CD34
  • Chronic myeloid leukemia

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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  • Cite this

    Muroi, K., Nakamurat, M., Amemiya, Y., Suda, T., & Miura, Y. (1995). Expression of c-kit receptor (CD 117) and CD34 in leukemic cells. Leukemia and Lymphoma, 16(3-4), 297-305. https://doi.org/10.3109/10428199509049769