Expression of c-kit receptor (CD 117) and CD34 in leukemic cells

Kazuo Muroi, Mitsuru Nakamurat, Youichi Amemiya, Toshio Suda, Yasusada Miura

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The expression of c-kit receptor (c-kit R; CD117) and CD34 was examined in acute myeloid leukemia (AML), acute lymphoid leukemia (ALL), chronic myeloid leukemia (CML) in blastic transformation (BT), and myelofibrosis (MF) in myeloid BT. In myeloid leukemia including AML, CML-myeloid BT and MF-myeloid BT, both c-kit R and CD34 were expressed synchronously, while in lymphoid leukemia including ALL and CML-lymphoid BT, only CD34 was highly expressed. A close correlation between c-kit R and CD33 expression and an inverse correlation between c-kit R and CD 19 expression were observed when all of the myeloid plus lymphoid leukemia cells were analysed. There was a close correlation between c-kit R and CD34 expression in the myeloid leukemia cells, c-kit R expression may be associated with myeloid phenotypes of leukemic cells and may be useful for the diagnosis of myeloid leukemia. The literature of c-kit R expression in leukemic cells is reviewed here and the comparison of c-kit R and CD34 expression in normal hematopoietic progenitor cells with those on the leukemic counterparts was discussed.

Original languageEnglish
Pages (from-to)297-305
Number of pages9
JournalLeukemia and Lymphoma
Volume16
Issue number3-4
DOIs
Publication statusPublished - 1995

Fingerprint

Proto-Oncogene Proteins c-kit
Myeloid Leukemia
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Lymphoid Leukemia
Primary Myelofibrosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute Myeloid Leukemia
Myeloid Cells
Hematopoietic Stem Cells
Lymphocytes
Phenotype

Keywords

  • Acute lymphoid leukemia
  • Acute myeloid leukemia
  • C-kit receptor
  • CD34
  • Chronic myeloid leukemia

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Muroi, K., Nakamurat, M., Amemiya, Y., Suda, T., & Miura, Y. (1995). Expression of c-kit receptor (CD 117) and CD34 in leukemic cells. Leukemia and Lymphoma, 16(3-4), 297-305. https://doi.org/10.3109/10428199509049769

Expression of c-kit receptor (CD 117) and CD34 in leukemic cells. / Muroi, Kazuo; Nakamurat, Mitsuru; Amemiya, Youichi; Suda, Toshio; Miura, Yasusada.

In: Leukemia and Lymphoma, Vol. 16, No. 3-4, 1995, p. 297-305.

Research output: Contribution to journalArticle

Muroi, K, Nakamurat, M, Amemiya, Y, Suda, T & Miura, Y 1995, 'Expression of c-kit receptor (CD 117) and CD34 in leukemic cells', Leukemia and Lymphoma, vol. 16, no. 3-4, pp. 297-305. https://doi.org/10.3109/10428199509049769
Muroi, Kazuo ; Nakamurat, Mitsuru ; Amemiya, Youichi ; Suda, Toshio ; Miura, Yasusada. / Expression of c-kit receptor (CD 117) and CD34 in leukemic cells. In: Leukemia and Lymphoma. 1995 ; Vol. 16, No. 3-4. pp. 297-305.
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