TY - JOUR
T1 - Expression of c-mos proto-oncogene in undifferentiated teratocarcinoma cells
AU - Ogiso, Yuko
AU - Matsumoto, Midori
AU - Morita, Takashi
AU - Nishino, Hoyoku
AU - Iwashima, Akio
AU - Matsushiro, Aizo
PY - 1986/10/30
Y1 - 1986/10/30
N2 - Proto-oncogene c-mos, the cellular homologue of the transforming gene of Molony murine sarcoma virus, has been characterized by the lack of expression in a variety of differentiated tissues, possibly because of the existence of an inhibitory upstream sequence. We detected mos-related transcripts in undifferentiated embryonal carcinoma cells of pluripotential cell line 311. The sizes of three major transcripts detected were estimated to be 1.8, 4.6 and 6.1-kilobases(kb) by northern analysis. Furthermore, these transcriptions were suppressed when the cell differentiation was induced by retinoic acid. Taken together, the results suggest that mos product plays a role in early stages of development.
AB - Proto-oncogene c-mos, the cellular homologue of the transforming gene of Molony murine sarcoma virus, has been characterized by the lack of expression in a variety of differentiated tissues, possibly because of the existence of an inhibitory upstream sequence. We detected mos-related transcripts in undifferentiated embryonal carcinoma cells of pluripotential cell line 311. The sizes of three major transcripts detected were estimated to be 1.8, 4.6 and 6.1-kilobases(kb) by northern analysis. Furthermore, these transcriptions were suppressed when the cell differentiation was induced by retinoic acid. Taken together, the results suggest that mos product plays a role in early stages of development.
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U2 - 10.1016/0006-291X(86)90757-6
DO - 10.1016/0006-291X(86)90757-6
M3 - Article
C2 - 3778463
AN - SCOPUS:0022968610
SN - 0006-291X
VL - 140
SP - 477
EP - 484
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -