Expression of cancer cachexia-related factors in human cancer xenografts

An immunohistochemical analysis

Shingo Kamoshida, Kana Watanabe, Mai Suzuki, Yasuyoshi Mizutani, Kazuki Sakamoto, Yoshikazu Sugimoto, Toshinori Oka, Masakazu Fukushima, Yutaka Tsutsumi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We immunohistochemically evaluated the involvement of five cancer cachexia-related factors, including leukemia-inhibitory factor (LIF), zinc-α2-glycoprotein (ZAG), interleukin 6 (IL-6), proteolysis-inducing factor (PIF) and tumor necrosis factor α (TNF α) in causing cancer cachexia. Twenty-six xenografts implanted into mice were examined for the expression of the cancer cachexia-related factors, in relation to the body weight loss of the hosts. Five xenografts were categorized in the cachectic group, and the remaining 21 xenografts belonged to the non-cachectic group. LIF was extensively expressed in both the cachectic and non-cachectic groups. ZAG and IL-6 were expressed in one of the cachectic and some non-cachectic xenografts. PIF and TNF α were detected in one and two non-cachectic xenografts, respectively, but in none of the cachectic ones. Any of five factors examined were not conclusive for causing cancer cachexia in the murine xenograft model. Further analysis is needed in order to elucidate the mechanisms responsible for cancer cachexia.

Original languageEnglish
Pages (from-to)275-281
Number of pages7
JournalBiomedical Research
Volume27
Issue number6
DOIs
Publication statusPublished - 2007 Jan 10
Externally publishedYes

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Cachexia
Heterografts
Proteolysis
Leukemia Inhibitory Factor
Neoplasms
Interleukin-6
Tumor Necrosis Factor-alpha
Zinc
Weight Loss
Glycoproteins
Body Weight

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Expression of cancer cachexia-related factors in human cancer xenografts : An immunohistochemical analysis. / Kamoshida, Shingo; Watanabe, Kana; Suzuki, Mai; Mizutani, Yasuyoshi; Sakamoto, Kazuki; Sugimoto, Yoshikazu; Oka, Toshinori; Fukushima, Masakazu; Tsutsumi, Yutaka.

In: Biomedical Research, Vol. 27, No. 6, 10.01.2007, p. 275-281.

Research output: Contribution to journalArticle

Kamoshida, S, Watanabe, K, Suzuki, M, Mizutani, Y, Sakamoto, K, Sugimoto, Y, Oka, T, Fukushima, M & Tsutsumi, Y 2007, 'Expression of cancer cachexia-related factors in human cancer xenografts: An immunohistochemical analysis', Biomedical Research, vol. 27, no. 6, pp. 275-281. https://doi.org/10.2220/biomedres.27.275
Kamoshida, Shingo ; Watanabe, Kana ; Suzuki, Mai ; Mizutani, Yasuyoshi ; Sakamoto, Kazuki ; Sugimoto, Yoshikazu ; Oka, Toshinori ; Fukushima, Masakazu ; Tsutsumi, Yutaka. / Expression of cancer cachexia-related factors in human cancer xenografts : An immunohistochemical analysis. In: Biomedical Research. 2007 ; Vol. 27, No. 6. pp. 275-281.
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