Expression of histamine H4 receptor in human synovial cells and dermal tissues

Yoshiko Matsuda; Katsunori Yamaura; Masahiko Suzuki; Takao Namiki; Koichi Ueno

doi:10.1007/978-90-481-9349-3_16

Expression of histamine H4 receptor in human synovial cells and dermal tissues

Yoshiko Matsuda, Katsunori Yamaura, Masahiko Suzuki, Takao Namiki, Koichi Ueno

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The last of the four histamine receptors, H4 receptor (H4R), was identified in the year 2000. Since that time, H4R has been implicated in cellular mechanisms related to immune systems, inflammatory processes, and allergic reactions. We reported the expression of H4R in rheumatoid arthritis (RA) synovial cell cultures and human dermal tissues. In the synovial cell cultures, two specific types of cell populations, fibroblast-like and macrophage-like cells, both showed expression of H4R. We also demonstrated H4R expression in human dermal fibroblast and epidermal tissue. When investigating the effect of histamine H4R antagonists on pruritus using a mouse model, JNJ7777120, a H4R antagonist, was found to significantly reduce histamine- and substance P-induced scratching. These results suggest that H4R may be useful for treatment rheumatoid arthritis or pruritus.

Original language	English
Title of host publication	Biomedical Aspects of Histamine
Subtitle of host publication	Current Perspectives
Publisher	Springer Netherlands
Pages	371-379
Number of pages	9
ISBN (Print)	9789048193486
DOIs	https://doi.org/10.1007/978-90-481-9349-3_16
Publication status	Published - 2011
Externally published	Yes

Keywords

H4R-antagonists
Histamine H4 receptors
Rheumatoid arthritis

ASJC Scopus subject areas

Engineering(all)

Access to Document

10.1007/978-90-481-9349-3_16

Cite this

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abstract = "The last of the four histamine receptors, H4 receptor (H4R), was identified in the year 2000. Since that time, H4R has been implicated in cellular mechanisms related to immune systems, inflammatory processes, and allergic reactions. We reported the expression of H4R in rheumatoid arthritis (RA) synovial cell cultures and human dermal tissues. In the synovial cell cultures, two specific types of cell populations, fibroblast-like and macrophage-like cells, both showed expression of H4R. We also demonstrated H4R expression in human dermal fibroblast and epidermal tissue. When investigating the effect of histamine H4R antagonists on pruritus using a mouse model, JNJ7777120, a H4R antagonist, was found to significantly reduce histamine- and substance P-induced scratching. These results suggest that H4R may be useful for treatment rheumatoid arthritis or pruritus.",

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AU - Yamaura, Katsunori

AU - Suzuki, Masahiko

AU - Namiki, Takao

AU - Ueno, Koichi

PY - 2011

Y1 - 2011

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Expression of histamine H4 receptor in human synovial cells and dermal tissues

Abstract

Keywords

ASJC Scopus subject areas

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