Expression of interleukin-6 in cerebral neurons and ovarian cancer tissue in Trousseau syndrome

S. Suzuki, K. Tanaka, S. Nogawa, A. Umezawa, J. Hata, Y. Fukuuchi

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Abstract

Interleukin-6 (IL-6) is reportedly increased in serum and CSF from acute stroke patients. However, the cellular origin and possible role of IL-6 in CNS after stroke are unclear. We describe a woman with recurrent stroke, disseminated intravascular coagulation (DIC) and non-bacterial thrombotic endocarditis (NBTE) caused by ovarian cancer (Trousseau syndrome). The patient died 50 days after the final episode of cerebral embolism. The immunohistochemical study revealed IL-6 protein to have been expressed both in cerebral neurons spared from ischemic insult and in epithelial cells of the ovarian tumor. We speculate that IL-6 produced in ovarian cancer may be associated with the hypercoagulable state and the development of NBTE in this patient. In contrast, IL-6 induction in cerebral neurons may contribute to the survival of these neurons after a stroke.

Original languageEnglish
Pages (from-to)232-235
Number of pages4
JournalClinical Neuropathology
Volume21
Issue number5
Publication statusPublished - 2002 Sep 1

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Keywords

  • Immunohistochemistry
  • Interleukin-6
  • Nonbacterial thrombotic endocarditis
  • Trousseau syndrome

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology

Cite this

Suzuki, S., Tanaka, K., Nogawa, S., Umezawa, A., Hata, J., & Fukuuchi, Y. (2002). Expression of interleukin-6 in cerebral neurons and ovarian cancer tissue in Trousseau syndrome. Clinical Neuropathology, 21(5), 232-235.