Expression of interstitial collagenase (matrix metalloproteinase-1) in gastric cancers

Yoshihiko Sakurai; Yoshihide Otani; Kaori Kameyama; Yasuhiro Hosoda; Isao Okazaki; Tetsuro Kubota; Koichiro Kumai; Masaki Kitajima

doi:10.1111/j.1349-7006.1997.tb00396.x

Expression of interstitial collagenase (matrix metalloproteinase-1) in gastric cancers

Yoshihiko Sakurai, Yoshihide Otani, Kaori Kameyama, Yasuhiro Hosoda, Isao Okazaki, Tetsuro Kubota, Koichiro Kumai, Masaki Kitajima

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

The expression of matrix metalloproteinase-1 (MMP-1) gene and the presence of MMP-1 protein in gastric cancer were examined by in situ hybridization and immunohistochemistry. Expression of the interstitial collagenase (MMP-1) gene was detected within the stroma of the neoplastic glands, and infiltration of eosinophils was observed to be associated with regions of MMP-1 gene expression. The degree of eosinophilic infiltration correlated with the level of MMP-1 mRNA expression. Immunostaining showed localization of MMP-1 protein in the stromal cells, and additionally in the neoplastic glands. These findings indicate that the stromal cells may play an important role in the expression of MMP-1, and suggest a pathophysiological role for MMP-1 in the invasion and metastasis of gastric cancer.

Original language	English
Pages (from-to)	401-406
Number of pages	6
Journal	Japanese Journal of Cancer Research
Volume	88
Issue number	4
DOIs	https://doi.org/10.1111/j.1349-7006.1997.tb00396.x
Publication status	Published - 1997
Externally published	Yes

Keywords

Collagenase
Eosinophil
Gastric cancer
Matrix metalloproteinase-1
Stromal cell

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1349-7006.1997.tb00396.x

Cite this

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title = "Expression of interstitial collagenase (matrix metalloproteinase-1) in gastric cancers",

abstract = "The expression of matrix metalloproteinase-1 (MMP-1) gene and the presence of MMP-1 protein in gastric cancer were examined by in situ hybridization and immunohistochemistry. Expression of the interstitial collagenase (MMP-1) gene was detected within the stroma of the neoplastic glands, and infiltration of eosinophils was observed to be associated with regions of MMP-1 gene expression. The degree of eosinophilic infiltration correlated with the level of MMP-1 mRNA expression. Immunostaining showed localization of MMP-1 protein in the stromal cells, and additionally in the neoplastic glands. These findings indicate that the stromal cells may play an important role in the expression of MMP-1, and suggest a pathophysiological role for MMP-1 in the invasion and metastasis of gastric cancer.",

keywords = "Collagenase, Eosinophil, Gastric cancer, Matrix metalloproteinase-1, Stromal cell",

author = "Yoshihiko Sakurai and Yoshihide Otani and Kaori Kameyama and Yasuhiro Hosoda and Isao Okazaki and Tetsuro Kubota and Koichiro Kumai and Masaki Kitajima",

year = "1997",

doi = "10.1111/j.1349-7006.1997.tb00396.x",

language = "English",

volume = "88",

pages = "401--406",

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T1 - Expression of interstitial collagenase (matrix metalloproteinase-1) in gastric cancers

AU - Sakurai, Yoshihiko

AU - Otani, Yoshihide

AU - Kameyama, Kaori

AU - Hosoda, Yasuhiro

AU - Okazaki, Isao

AU - Kubota, Tetsuro

AU - Kumai, Koichiro

AU - Kitajima, Masaki

PY - 1997

Y1 - 1997

N2 - The expression of matrix metalloproteinase-1 (MMP-1) gene and the presence of MMP-1 protein in gastric cancer were examined by in situ hybridization and immunohistochemistry. Expression of the interstitial collagenase (MMP-1) gene was detected within the stroma of the neoplastic glands, and infiltration of eosinophils was observed to be associated with regions of MMP-1 gene expression. The degree of eosinophilic infiltration correlated with the level of MMP-1 mRNA expression. Immunostaining showed localization of MMP-1 protein in the stromal cells, and additionally in the neoplastic glands. These findings indicate that the stromal cells may play an important role in the expression of MMP-1, and suggest a pathophysiological role for MMP-1 in the invasion and metastasis of gastric cancer.

AB - The expression of matrix metalloproteinase-1 (MMP-1) gene and the presence of MMP-1 protein in gastric cancer were examined by in situ hybridization and immunohistochemistry. Expression of the interstitial collagenase (MMP-1) gene was detected within the stroma of the neoplastic glands, and infiltration of eosinophils was observed to be associated with regions of MMP-1 gene expression. The degree of eosinophilic infiltration correlated with the level of MMP-1 mRNA expression. Immunostaining showed localization of MMP-1 protein in the stromal cells, and additionally in the neoplastic glands. These findings indicate that the stromal cells may play an important role in the expression of MMP-1, and suggest a pathophysiological role for MMP-1 in the invasion and metastasis of gastric cancer.

KW - Collagenase

KW - Eosinophil

KW - Gastric cancer

KW - Matrix metalloproteinase-1

KW - Stromal cell

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Expression of interstitial collagenase (matrix metalloproteinase-1) in gastric cancers

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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