Expression of interstitial collagenase (matrix metalloproteinase-1) in gastric cancers

Yoshihiko Sakurai, Yoshihide Otani, Kaori Kameyama, Yasuhiro Hosoda, Isao Okazaki, Tetsuro Kubota, Koichiro Kumai, Masaki Kitajima

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The expression of matrix metalloproteinase-1 (MMP-1) gene and the presence of MMP-1 protein in gastric cancer were examined by in situ hybridization and immunohistochemistry. Expression of the interstitial collagenase (MMP-1) gene was detected within the stroma of the neoplastic glands, and infiltration of eosinophils was observed to be associated with regions of MMP-1 gene expression. The degree of eosinophilic infiltration correlated with the level of MMP-1 mRNA expression. Immunostaining showed localization of MMP-1 protein in the stromal cells, and additionally in the neoplastic glands. These findings indicate that the stromal cells may play an important role in the expression of MMP-1, and suggest a pathophysiological role for MMP-1 in the invasion and metastasis of gastric cancer.

Original languageEnglish
Pages (from-to)401-406
Number of pages6
JournalJapanese Journal of Cancer Research
Volume88
Issue number4
Publication statusPublished - 1997

Fingerprint

Matrix Metalloproteinase 1
Stomach Neoplasms
Stromal Cells
Eosinophils
Genes
In Situ Hybridization
Proteins
Immunohistochemistry
Neoplasm Metastasis
Gene Expression
Messenger RNA

Keywords

  • Collagenase
  • Eosinophil
  • Gastric cancer
  • Matrix metalloproteinase-1
  • Stromal cell

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Sakurai, Y., Otani, Y., Kameyama, K., Hosoda, Y., Okazaki, I., Kubota, T., ... Kitajima, M. (1997). Expression of interstitial collagenase (matrix metalloproteinase-1) in gastric cancers. Japanese Journal of Cancer Research, 88(4), 401-406.

Expression of interstitial collagenase (matrix metalloproteinase-1) in gastric cancers. / Sakurai, Yoshihiko; Otani, Yoshihide; Kameyama, Kaori; Hosoda, Yasuhiro; Okazaki, Isao; Kubota, Tetsuro; Kumai, Koichiro; Kitajima, Masaki.

In: Japanese Journal of Cancer Research, Vol. 88, No. 4, 1997, p. 401-406.

Research output: Contribution to journalArticle

Sakurai, Y, Otani, Y, Kameyama, K, Hosoda, Y, Okazaki, I, Kubota, T, Kumai, K & Kitajima, M 1997, 'Expression of interstitial collagenase (matrix metalloproteinase-1) in gastric cancers', Japanese Journal of Cancer Research, vol. 88, no. 4, pp. 401-406.
Sakurai, Yoshihiko ; Otani, Yoshihide ; Kameyama, Kaori ; Hosoda, Yasuhiro ; Okazaki, Isao ; Kubota, Tetsuro ; Kumai, Koichiro ; Kitajima, Masaki. / Expression of interstitial collagenase (matrix metalloproteinase-1) in gastric cancers. In: Japanese Journal of Cancer Research. 1997 ; Vol. 88, No. 4. pp. 401-406.
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