TY - JOUR
T1 - Expression of laminin-5-γ-2 chain in intraductal papillary-mucinous and invasive ductal tumors of the pancreas
AU - Fukushima, Noriyoshi
AU - Sakamoto, Michiie
AU - Hirohashi, Setsuo
N1 - Funding Information:
Copyright © 2001 by The United States and Canadian Academy of Pathology, Inc. VOL. 14, NO. 5, P. 404, 2001 Printed in the U.S.A. Date of acceptance: January 4, 2001. This research was supported in part by a Grant-in-Aid for Second Term Comprehensive 10-year Strategy for Cancer Control from the Ministry of Health and Welfare, Japan. Address reprint requests to: Setsuo Hirohashi, M.D., Pathology Division, National Cancer Center Research Institute, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan; email: shirohas@ncc.go.jp; fax: +81-3-3248-2463.
PY - 2001/5
Y1 - 2001/5
N2 - The laminin-5-γ-2 chain is expressed in various invasive carcinoma cells. To clarify the relationship between laminin-5 expression and the development of intraductal papillary-mucinous tumors (IPMTs), we performed an immunohistochemical study of 26 IPMTs and 30 invasive ductal adenocarcinomas. Cases were classified into five groups: intraductal papillary-mucinous adenoma (Group A; n = 8), adenocarcinoma without invasion (Group B; n = 3), adenocarcinoma with minimal invasion (Group C; n = 5), adenocarcinoma with macroscopically evident invasion (Group D; n = 10), and invasive ductal adenocarcinoma (conventional type; Group E; n = 30). In the invasive components of Groups D and E, laminin-5 was expressed in 80% and 100% of cases, respectively. In the intraductal components of IPMTs, expression of laminin-5 was not seen in Groups A and B, whereas they were seen in one case in Group C (20%) and in seven in Group D (70%). Most of the staining patterns of the intraductal components were focal and scattered. Laminin-5-γ-2 expression in the intraductal components of IPMTs tends to increase as tumors develop and may be a indicator of the potential invasiveness of the tumor cells.
AB - The laminin-5-γ-2 chain is expressed in various invasive carcinoma cells. To clarify the relationship between laminin-5 expression and the development of intraductal papillary-mucinous tumors (IPMTs), we performed an immunohistochemical study of 26 IPMTs and 30 invasive ductal adenocarcinomas. Cases were classified into five groups: intraductal papillary-mucinous adenoma (Group A; n = 8), adenocarcinoma without invasion (Group B; n = 3), adenocarcinoma with minimal invasion (Group C; n = 5), adenocarcinoma with macroscopically evident invasion (Group D; n = 10), and invasive ductal adenocarcinoma (conventional type; Group E; n = 30). In the invasive components of Groups D and E, laminin-5 was expressed in 80% and 100% of cases, respectively. In the intraductal components of IPMTs, expression of laminin-5 was not seen in Groups A and B, whereas they were seen in one case in Group C (20%) and in seven in Group D (70%). Most of the staining patterns of the intraductal components were focal and scattered. Laminin-5-γ-2 expression in the intraductal components of IPMTs tends to increase as tumors develop and may be a indicator of the potential invasiveness of the tumor cells.
KW - Immunohistochemistry
KW - Intraductal papillary-mucinous tumor
KW - Laminin-5-γ-2 chain
KW - Pancreas
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U2 - 10.1038/modpathol.3880326
DO - 10.1038/modpathol.3880326
M3 - Article
C2 - 11353049
AN - SCOPUS:0035026775
SN - 0893-3952
VL - 14
SP - 404
EP - 409
JO - Modern Pathology
JF - Modern Pathology
IS - 5
ER -