Expression of matrix metalloproteinase-1 mRNA related to eosinophilia and interleukin-5 gene expression in head and neck tumour tissue

Yoshihiro Ono, Masato Fujii, Kaori Kameyama, Yoshihide Otani, Yoshihiko Sakurai, Jin Kanzaki

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In situ hybridization (ISH) of the expression of matrix metalloproteinase-1 (MMP-1) in areas of local invasion of head and neck tumours was performed. Expression of MMP-1 mRNA was found in stromal inflammatory cells adjacent to the tumour nests, apparently in eosinophils. MMP-1 mRNA expression was seen only in cases with moderate or greater stromal eosinophilia. MMP-1 mRNA was detected in benign papilloma and verrucous carcinoma. In squamous cell carcinomas, expression of the gene was detected only in well-differentiated cases. Expression of MMP-1 mRNA was not related to the grade of malignancy, and appeared in stromal eosinophils, suggesting to us that it is involved in a remodelling process in the reaction of the host to tumour invasion. ISH examination of the expression of interleukin-5 (IL-5), the activating factor for eosinophils, was also performed. In the tumour, its expression was consistent with the location of eosinophils, as with MMP-1 mRNA, suggesting an autocrine mechanism.

Original languageEnglish
Pages (from-to)305-310
Number of pages6
JournalVirchows Archiv
Volume431
Issue number5
DOIs
Publication statusPublished - 1997

Fingerprint

Matrix Metalloproteinase 1
Interleukin-5
Eosinophilia
Neck
Head
Gene Expression
Messenger RNA
Eosinophils
Neoplasms
In Situ Hybridization
Verrucous Carcinoma
Papilloma
Stromal Cells
Squamous Cell Carcinoma

Keywords

  • Eosinophil
  • Head and neck tumour
  • IL-5
  • In situ hybridization
  • Matrix metalloproteinase

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Expression of matrix metalloproteinase-1 mRNA related to eosinophilia and interleukin-5 gene expression in head and neck tumour tissue. / Ono, Yoshihiro; Fujii, Masato; Kameyama, Kaori; Otani, Yoshihide; Sakurai, Yoshihiko; Kanzaki, Jin.

In: Virchows Archiv, Vol. 431, No. 5, 1997, p. 305-310.

Research output: Contribution to journalArticle

Ono, Yoshihiro ; Fujii, Masato ; Kameyama, Kaori ; Otani, Yoshihide ; Sakurai, Yoshihiko ; Kanzaki, Jin. / Expression of matrix metalloproteinase-1 mRNA related to eosinophilia and interleukin-5 gene expression in head and neck tumour tissue. In: Virchows Archiv. 1997 ; Vol. 431, No. 5. pp. 305-310.
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AU - Sakurai, Yoshihiko

AU - Kanzaki, Jin

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