Expression of matrix metalloproteinase-1 mRNA related to eosinophilia and interleukin-5 gene expression in head and neck tumour tissue

Yoshihiro Ono, Masato Fujii, Kaori Kameyama, Yoshihide Otani, Yoshihiko Sakurai, Jin Kanzaki

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In situ hybridization (ISH) of the expression of matrix metalloproteinase-1 (MMP-1) in areas of local invasion of head and neck tumours was performed. Expression of MMP-1 mRNA was found in stromal inflammatory cells adjacent to the tumour nests, apparently in eosinophils. MMP-1 mRNA expression was seen only in cases with moderate or greater stromal eosinophilia. MMP-1 mRNA was detected in benign papilloma and verrucous carcinoma. In squamous cell carcinomas, expression of the gene was detected only in well-differentiated cases. Expression of MMP-1 mRNA was not related to the grade of malignancy, and appeared in stromal eosinophils, suggesting to us that it is involved in a remodelling process in the reaction of the host to tumour invasion. ISH examination of the expression of interleukin-5 (IL-5), the activating factor for eosinophils, was also performed. In the tumour, its expression was consistent with the location of eosinophils, as with MMP-1 mRNA, suggesting an autocrine mechanism.

Original languageEnglish
Pages (from-to)305-310
Number of pages6
JournalVirchows Archiv
Volume431
Issue number5
DOIs
Publication statusPublished - 1997 Nov 25

Keywords

  • Eosinophil
  • Head and neck tumour
  • IL-5
  • In situ hybridization
  • Matrix metalloproteinase

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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