Expression of matrix metalloproteinases and aggrecanase in the synovial fluids of patients with symptomatic temporomandibular disorders

Kan Yoshida, Shigeyuki Takatsuka, Eriko Hatada, Hiroyuki Nakamura, Akira Tanaka, Koichiro Ueki, Kiyomasa Nakagawa, Yasunori Okada, Etsuhide Yamamoto, Ryuuzi Fukuda

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Abstract

Objective: To investigate whether matrix metalloproteinases (MMPs) and/or aggrecanase in synovial fluid can be used as biochemical markers in the diagnosis of internal derangement (ID) of the temporomandibular joint (TMJ). Study design: Forty-four samples of synovial fluid were obtained from 35 patients with ID and osteoarthritis (OA) and 15 normal samples from 10 asymptomatic volunteers. MMP-2, -9, and aggrecanase in the synovial fluid were examined by immunoblotting. Results: The incidences of MMP-2, -9, and aggrecanase expression in the ID and OA group were significantly higher than those in the normal group (P < .05). Those with anterior disc displacement without reduction and severe OA showed significantly high expression of MMP-9 compared with other disease subgroups (P < .05). Conversely, comparatively high expression of MMP-2 and aggrecanase was shown in the early-stage OA group. However, there was no significant difference in expression of MMP-2 and aggrecanase among disease subgroups. Conclusions: These findings suggested that expression of aggrecanase could be a potential biochemical marker for articular cartilage degradation in ID of the TMJ.

Original languageEnglish
Pages (from-to)22-27
Number of pages6
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
Volume102
Issue number1
DOIs
Publication statusPublished - 2006 Jul

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Temporomandibular Joint Disorders
Synovial Fluid
Matrix Metalloproteinases
Matrix Metalloproteinase 2
Osteoarthritis
Matrix Metalloproteinase 9
Temporomandibular Joint
Biomarkers
Articular Cartilage
Immunoblotting
aggrecanase
Volunteers
Incidence

ASJC Scopus subject areas

  • Dentistry(all)
  • Pathology and Forensic Medicine
  • Radiology Nuclear Medicine and imaging
  • Surgery

Cite this

Expression of matrix metalloproteinases and aggrecanase in the synovial fluids of patients with symptomatic temporomandibular disorders. / Yoshida, Kan; Takatsuka, Shigeyuki; Hatada, Eriko; Nakamura, Hiroyuki; Tanaka, Akira; Ueki, Koichiro; Nakagawa, Kiyomasa; Okada, Yasunori; Yamamoto, Etsuhide; Fukuda, Ryuuzi.

In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, Vol. 102, No. 1, 07.2006, p. 22-27.

Research output: Contribution to journalArticle

Yoshida, Kan ; Takatsuka, Shigeyuki ; Hatada, Eriko ; Nakamura, Hiroyuki ; Tanaka, Akira ; Ueki, Koichiro ; Nakagawa, Kiyomasa ; Okada, Yasunori ; Yamamoto, Etsuhide ; Fukuda, Ryuuzi. / Expression of matrix metalloproteinases and aggrecanase in the synovial fluids of patients with symptomatic temporomandibular disorders. In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology. 2006 ; Vol. 102, No. 1. pp. 22-27.
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